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PMVK Antikörper (Middle Region)

PMVK Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044328
  • Target Alle PMVK Antikörper anzeigen
    PMVK (Phosphomevalonate Kinase (PMVK))
    Bindungsspezifität
    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 135-151, Middle Region
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 28
    • 8
    Kaninchen
    Klonalität
    • 30
    • 6
    Polyklonal
    Konjugat
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PMVK Antikörper ist unkonjugiert
    Applikation
    • 32
    • 12
    • 12
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-Phosphomevalonate kinase PMVK Antibody Picoband®
    Sequenz
    EQSRQQRGWV FTPGVDD
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Phosphomevalonate kinase PMVK Antibody (ABIN3044328). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human PMVK, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product PMVK Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human, Mouse
    Western blot, 0.1-0.5 μg/mL, Rat, Human, Mouse
    1. Olivier, L. M., Chambliss, K. L., Gibson, K. M., Krisans, S. K. : Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J. Lipid Res. 40: 672-679, 1999. 2. Chambliss, K. L., Slaughter, C. A., Schreiner, R., Hoffmann, G. F., Gibson, K. M. : Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J. Biol. Chem. 271: 17330-17334, 1996.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    PMVK (Phosphomevalonate Kinase (PMVK))
    Andere Bezeichnung
    PMVK (PMVK Produkte)
    Hintergrund

    Synonyms: Phosphomevalonate kinase,PMKase,hPMK,2.7.4.2,PMVK,PMKI,

    Tissue Specificity: Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. .

    Background: PMVK (phosphomevalonate kinase) is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.

    Molekulargewicht
    77 kDa
    UniProt
    Q15126
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