TFF1 Antikörper (Middle Region)

Produktnummer ABIN3044264

Produktdetails anti-TFF1 Antikörper

Target: TFF1 (Trefoil Factor 1 (TFF1))

Bindungsspezifität: AA 59-72, Middle Region

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TFF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Trefoil factor 1(TFF1) detection. Tested with WB, IHC-P in Mouse,Rat.

Sequenz: CCFDDSVRGF PWCF

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Trefoil factor 1(TFF1) detection. Tested with WB, IHC-P in Mouse,Rat.
Gene Name: trefoil factor 1
Protein Name: Trefoil factor 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse Estrogen Inducible Protein pS2(59-72aa CCFDDSVRGFPWCF), identical to the related rat sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Andere Bezeichnung: TFF1 (TFF1 Produkte)

Synonyme: BCEI antikoerper, D21S21 antikoerper, HP1.A antikoerper, HPS2 antikoerper, pNR-2 antikoerper, pS2 antikoerper, Bcei antikoerper, PS2 antikoerper, bcei antikoerper, d21s21 antikoerper, hp1.a antikoerper, hps2 antikoerper, p1 antikoerper, p1-a antikoerper, pnr-2 antikoerper, ps2 antikoerper, tff1 antikoerper, xP1 antikoerper, xp1-L antikoerper, xp1 antikoerper, TFF1 antikoerper, Ps2 antikoerper, trefoil factor 1 antikoerper, trefoil factor 1 S homeolog antikoerper, trefoil factor 1, gene 2 S homeolog antikoerper, TFF1 antikoerper, Tff1 antikoerper, tff1.S antikoerper, tff1.2.S antikoerper, LOC100358238 antikoerper

Hintergrund: TFF1(Trefoil factor 1), also known as pS2, is a protein that in humans is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. It is found that TFF1 in normal human urine inhibited the growth of calcium oxalate crystals. Urinary TFF1 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by TFF1 antisera, particularly by antisera directed to the TFF1 C terminus. Concentrations and relative amounts of TFF1 in the urine of patients with idiopathic calcium oxalate kidney stones were significantly less than those found in controls. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Synonyms: BCEI antibody|Breast cancer estrogen inducible protein antibody|Breast cancer estrogen inducible sequence antibody|Breast cancer estrogen-inducible protein antibody|D21S21 antibody|Gastrointestinal trefoil protein antibody|Gastrointestinal trefoil protein pS2 antibody|hP1.A antibody|HP1A antibody|HPS 2 antibody|HPS2 antibody|pNR 2 antibody|PNR-2 antibody|pNR2 antibody|Polypeptide P1.A antibody|Protein pS2 antibody|PS 2 antibody|pS2 antibody|pS2 protein antibody|TFF 1 antibody|TFF1 antibody|TFF1_HUMAN antibody|Trefoil factor 1 antibody

UniProt: Q08423

Pathways: EGFR Signaling Pathway