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ITGA3 Antikörper (N-Term)

ITGA3 Reaktivität: Human, Ratte WB, FACS, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044222
  • Target Alle ITGA3 Antikörper anzeigen
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Bindungsspezifität
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-67, N-Term
    Reaktivität
    • 53
    • 22
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 34
    • 20
    • 3
    • 1
    Kaninchen
    Klonalität
    • 38
    • 22
    Polyklonal
    Konjugat
    • 36
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITGA3 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 23
    • 20
    • 14
    • 12
    • 8
    • 7
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-Integrin alpha 3/ITGA3 Antibody Picoband®
    Sequenz
    LFGYSVALHR QTERQQR
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Integrin alpha 3/ITGA3 Antibody (ABIN3044222). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3, identical to the related rat and mouse sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product ITGA3 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    1. Akula, S. M., Pramod, N. P., Wang, F.-Z., Chandran, B. Integrin alpha-3/beta-1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108: 407-419, 2002. 2. Dulabon, L., Olson, E. C., Taglienti, M. G., Eisenhuth, S., McGrath, B., Walsh, C. A., Kreidberg, J. A., Anton, E. S. Reelin binds alpha-3-beta-1 integrin and inhibits neuronal migration. Neuron 27: 33-44, 2000. 3. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen".
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Andere Bezeichnung
    ITGA3 (ITGA3 Produkte)
    Hintergrund

    Synonyms: Integrin alpha-3,CD49 antigen-like family member C,FRP-2,Galactoprotein B3,GAPB3,VLA-3 subunit alpha,CD49c,Integrin alpha-3 heavy chain,Integrin alpha-3 light chain,ITGA3,MSK18,

    Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. .

    Background: ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.

    Sequence Similarities: Belongs to the integrin alpha chain family.

    Molekulargewicht
    155 kDa
    UniProt
    P26006
    Pathways
    CXCR4-mediated Signaling Events, Integrin Complex
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