Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

NOX1 Antikörper (Middle Region)

Der Kaninchen Polyklonal Anti-NOX1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, NOX1 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN3044132

Kurzübersicht für NOX1 Antikörper (Middle Region) (ABIN3044132)

Target

Alle NOX1 Antikörper anzeigen
NOX1 (NADPH Oxidase 1 (NOX1))

Reaktivität

  • 44
  • 10
  • 7
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 44
  • 4
  • 1
Kaninchen

Klonalität

  • 46
  • 4
Polyklonal

Konjugat

  • 34
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NOX1 Antikörper ist unkonjugiert

Applikation

  • 37
  • 23
  • 16
  • 8
  • 8
  • 6
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 8
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 354-374, Middle Region

    Verwendungszweck

    Anti-NADPH oxidase 1 NOX1 Antibody Picoband®

    Sequenz

    HIRAAGDWTE NLIRAFEQQY S

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-NADPH oxidase 1 NOX1 Antibody (ABIN3044132). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human NOX1.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Banfi, B., Maturana, A., Jaconi, S., Arnaudeau, S., Laforge, T., Sinha, S., Ligeti, E., Demaurex, N., Krause, K.-H. A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287: 138-141, 2000. 2. Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., Dugan, L. L. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 318: 1645-1647, 2007. 3. Lachgar A, Sojic N, Arbault S, et al. (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins."

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Liu, Hong, Li, Ren, Wang, Xu, Shi, Xu: "A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis." in: Antioxidants & redox signaling, (2018) (PubMed).

    Wang, Wang, Liu, Wang, Zhao, Wang, Yin: "Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells." in: Carbohydrate polymers, Vol. 125, pp. 135-45, (2015) (PubMed).

    Gu, Gong, Zhang, Dong, Zhao, Burczynski, Wang, Sun, Zhu, Han, Wang, Li: "Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 91, Issue 3, pp. 187-93, (2013) (PubMed).

  • Target

    NOX1 (NADPH Oxidase 1 (NOX1))

    Andere Bezeichnung

    NOX1

    Hintergrund

    Synonyms: NADPH oxidase 1,NOX-1,1.-.-.-,Mitogenic oxidase 1,MOX-1,NADH/NADPH mitogenic oxidase subunit P65-MOX,NOH-1,NOX1,MOX1, NOH1,

    Tissue Specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells.

    Background: NOX1 (NADPH OXIDASE 1), also known as NOH1, MOX1 or GP91-2, is an enzyme that in humans is encoded by the NOX1 gene. It is also a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. The NOX1 gene is mapped to Xq22.1. NOX1 was expressed in colon, prostate, uterus, and vascular smooth muscle, but not in peripheral blood leukocytes. The deduced 564-amino acid NOX1 protein, which is 58 % identical to CYBB, contains 6 membrane-spanning regions, conserved flavin and pyridine nucleotide-binding sites, and histidines possibly involved in heme ligation. Overexpression of MOX1 in NIH 3T3 cells increased superoxide generation and cell growth. Cells expressing MOX1 had a transformed appearance, showed anchorage-independent growth, and produced tumors in athymic mice. Disruption of either Nox1 or Nox2 significantly delayed progression of motor neuron disease in these mice. However, 50 % survival rates were enhanced significantly more by Nox2 deletion than Nox1 deletion.

    Sequence Similarities: Contains 1 FAD-binding FR-type domain.

    Molekulargewicht

    65 kDa

    UniProt

    Q9Y5S8

    Pathways

    Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport
Sie sind hier:
Chat with us!