2B4 Antikörper (C-Term)

Produktnummer ABIN3044068

Produktdetails anti-2B4 Antikörper

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Bindungsspezifität: AA 357-370, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 2B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Natural killer cell receptor 2B4(CD244) detection. Tested with WB, IHC-P in Human.

Sequenz: RLSRKELENF DVYS

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Natural killer cell receptor 2B4(CD244) detection. Tested with WB, IHC-P in Human.
Gene Name: CD244 Molecule, natural killer cell receptor 2B4
Protein Name: Natural killer cell receptor 2B4

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD244(357-370aa RLSRKELENFDVYS).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Andere Bezeichnung: CD244 (CD244 Produkte)

Synonyme: CD244 antikoerper, 2B4 antikoerper, NAIL antikoerper, NKR2B4 antikoerper, Nmrk antikoerper, SLAMF4 antikoerper, C9.1 antikoerper, F730046O15Rik antikoerper, Ly90 antikoerper, CD244 molecule antikoerper, CD244 natural killer cell receptor 2B4 antikoerper, CD244 antikoerper, Cd244 antikoerper

Hintergrund: CD244(Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al.(1999) mapped the 2B4 gene to 1q22. Suzuki et al.(2008) identified a functional single-nucleotide polymorphism(SNP) in the CD244 gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al.(1999) demonstrated that engagement of 2B4 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand 2B4 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al.(1998) demonstrated that CD48 binds to 2B4. Watzl et al.(2000) showed that antibody-mediated cross-linking of 2B4 leads to its rapid tyrosine phosphorylation, which is necessary for 2B4-mediated killer cell activity.

Synonyms: 2B4 antibody|C9.1 antibody|CD244 antibody|CD244 antigen antibody|CD244 Molecule natural killer cell receptor 2B4 antibody|CD244 natural killer cell receptor 2B4 antibody|CD244_HUMAN antibody|F730046O15Rik antibody|h2B4 antibody|Ly90 antibody|NAIL antibody|Natural killer cell activation-inducing ligand antibody|Natural killer cell receptor 2B4 antibody|NK cell activation inducing ligand antibody|NK cell activation inducing ligand NAIL antibody|NK cell activation-inducing ligand antibody|NK cell type I receptor protein 2B4 antibody|NKR2B4 antibody|Nmrk antibody|Non-MHC restricted killing associated antibody|OTTHUMP00000027884 antibody|p38 antibody|SLAM family, member 4 antibody|SLAMF4 antibody