EGR1 Antikörper (N-Term)
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- Target Alle EGR1 Antikörper anzeigen
- EGR1 (Early Growth Response 1 (EGR1))
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Bindungsspezifität
- AA 23-43, N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EGR1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Verwendungszweck
- Anti-Egr1 Antibody Picoband®
- Sequenz
- FPHSPTMDNY PKLEEMMLLS N
- Kreuzreaktivität (Details)
- No cross-reactivity with other proteins
- Produktmerkmale
- Anti-Egr1 Antibody (ABIN3043997). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the N-terminus of human Egr1, identical to the related rat and mouse sequences.
- Isotyp
- IgG
- Top Product
- Discover our top product EGR1 Primärantikörper
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- Applikationshinweise
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Western blot, 0.1-0.5 μg/mL, Human
1. Das, A., Chendil, D., Dey, S., Mohiuddin, M., Mohiuddin, M., Milbrandt, J., Rangnekar, V. M., Ahmed, M. M. Ionizing radiation down-regulates p53 protein in primary Egr-1(-/-) mouse embryonic fibroblast cells causing enhanced resistance to apoptosis. J. Biol. Chem. 276: 3279-3286, 2001. 2. Joslin, J. M., Fernald, A. A., Tennant, T. R., Davis, E. M., Kogan, S. C., Anastasi, J., Crispino, J. D., Le Beau, M. M. Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 110: 719-726, 2007. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. - Haltbarkeit
- 12 months
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ERK/Egr-1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells." in: European journal of cell biology, Vol. 93, Issue 7, pp. 278-88, (2014) (PubMed).
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ERK/Egr-1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells." in: European journal of cell biology, Vol. 93, Issue 7, pp. 278-88, (2014) (PubMed).
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- Target
- EGR1 (Early Growth Response 1 (EGR1))
- Andere Bezeichnung
- EGR1 (EGR1 Produkte)
- Hintergrund
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Synonyms: Early growth response protein 1,EGR-1,AT225,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protein 225,Zinc finger protein Krox-24,EGR1,KROX24, ZNF225,
Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.
Background: Earlu growth response protein 1, also known as ZIF268 or NGFIA, is a protein that in humans is encoded by the EGR1 gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. This gene is mapped to 5q31.2. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity.
Sequence Similarities: Belongs to the EGR C2H2-type zinc-finger protein family.
- Molekulargewicht
- 58 kDa
- UniProt
- P18146
- Pathways
- Regulation of Carbohydrate Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
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