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beta Arrestin 1 Antikörper (N-Term)

ARRB1 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043990
  • Target Alle beta Arrestin 1 (ARRB1) Antikörper anzeigen
    beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
    Bindungsspezifität
    • 19
    • 11
    • 8
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 82-103, N-Term
    Reaktivität
    • 76
    • 49
    • 32
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 82
    • 11
    • 1
    Kaninchen
    Klonalität
    • 73
    • 21
    Polyklonal
    Konjugat
    • 58
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser beta Arrestin 1 Antikörper ist unkonjugiert
    Applikation
    • 72
    • 40
    • 34
    • 28
    • 17
    • 13
    • 13
    • 12
    • 12
    • 12
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-beta Arrestin 1/ARRB1 Antibody Picoband®
    Sequenz
    ANVQSFPPAP EDKKPLTRLQ ER
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-beta Arrestin 1/ARRB1 Antibody (ABIN3043990). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human beta Arrestin 1, identical to the related rat and mouse sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product ARRB1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., DuBois, R. N. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc. Nat. Acad. Sci. 103: 1492-1497, 2006. 2. Nelson, C. D., Perry, S. J., Regier, D. S., Prescott, S. M., Topham, M. K., Lefkowitz, R. J.Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science 315: 663-666, 2007.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
    Andere Bezeichnung
    ARRB1 (ARRB1 Produkte)
    Hintergrund

    Synonyms: Beta-arrestin-1;Arrestin beta-1;ARRB1;ARR1;

    Background: Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization, this gene is mapped to 11q13.4. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.

    Sequence Similarities: Belongs to the arrestin family.

    Molekulargewicht
    18 kDa
    UniProt
    P49407
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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