TACR1 Antikörper (C-Term)

Produktnummer ABIN3043942

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TACR1 in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für TACR1 Antikörper (C-Term) (ABIN3043942)

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TACR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TACR1 Antikörper

Bindungsspezifität: AA 264-291, C-Term

Verwendungszweck: Anti-Neurokinin 1 Receptor/TACR1 Antibody Picoband®

Sequenz: FHIFFLLPYI NPDLYLKKFI QQVYLAIM

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Neurokinin 1 Receptor/TACR1 Antibody Picoband® (ABIN3043942). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TACR1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Castagliuolo, I., Riegler, M., Pasha, A., Nikulasson, S., Lu, B., Gerard, C., Gerard, N. P., Pothoulakis, C.Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis.J. Clin. Invest. 101: 1547-1550, 1998. 2. George, D. T., Gilman, J., Hersh, J., Thorsell, A., Herion, D., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R., Brandt, J. E., Gehlert, D. R., Tauscher, J. T., Hunt, S. P., Hommer, D., Heilig, M.Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.Science 319: 1536-1539, 2008. 3. Lai, J.-P., Ho, W. Z., Kilpatrick, L. E., Wang, X., Tuluc, F., Korchak, H. M., Douglas, S. D.Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.Proc. Nat. Acad. Sci. 103: 7771-7776, 2006.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu TACR1

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Andere Bezeichnung: TACR1

Hintergrund:

Synonyms: Substance-P receptor,SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1,TACR1,NK1R, TAC1R,

Tissue Specificity: Ubiquitously expressed. .

Background: The tachykinin receptor 1 (TACR1), also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR), is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Molekulargewicht: 55 kDa

Gen-ID: 6869

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration