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EWSR1 Antikörper (Middle Region)

EWSR1 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ICC, FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043825
  • Target Alle EWSR1 Antikörper anzeigen
    EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 369-399, Middle Region
    Reaktivität
    • 65
    • 30
    • 24
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 53
    • 10
    • 2
    • 1
    Kaninchen
    Klonalität
    • 55
    • 11
    Polyklonal
    Konjugat
    • 48
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EWSR1 Antikörper ist unkonjugiert
    Applikation
    • 56
    • 26
    • 16
    • 15
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Verwendungszweck
    Anti-EWSR1 Antibody Picoband®
    Sequenz
    NDSVTLDDLA DFFKQCGVVK MNKRTGQPMI H
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-EWSR1 Antibody Picoband® (ABIN3043825). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human EWSR1, different from the related mouse sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product EWSR1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. "Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1". 2. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G (October 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature 359 (6391): 162-5.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))
    Andere Bezeichnung
    EWSR1 (EWSR1 Produkte)
    Hintergrund

    Synonyms: RNA-binding protein EWS,EWS oncogene,Ewing sarcoma breakpoint region 1 protein,EWSR1,EWS,

    Tissue Specificity: Ubiquitous.

    Background: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11,22) (q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

    Sequence Similarities: Belongs to the RRM TET family.

    Molekulargewicht
    95 kDa
    Gen-ID
    2130
    UniProt
    Q01844
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