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COMT Antikörper (AA 52-271)

Dieses Anti-COMT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von COMT in WB, IHC und ICC. Geeignet für Human, Ratte und Maus.
Produktnummer ABIN3043815

Kurzübersicht für COMT Antikörper (AA 52-271) (ABIN3043815)

Target

Alle COMT Antikörper anzeigen
COMT (Catechol-O-Methyltransferase (COMT))

Reaktivität

  • 60
  • 49
  • 41
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 70
  • 23
  • 3
  • 1
Kaninchen

Klonalität

  • 66
  • 31
Polyklonal

Konjugat

  • 65
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser COMT Antikörper ist unkonjugiert

Applikation

  • 62
  • 41
  • 28
  • 26
  • 24
  • 13
  • 13
  • 10
  • 8
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 52-271

    Verwendungszweck

    Anti-COMT Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-COMT Antibody Picoband® (ABIN3043815). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human COMT recombinant protein (Position: G52-P271). Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunocytochemistry , 0.5-1 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
    Western blot, 0.1-0.5 μg/mL
    1. Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P., Skuse, D. COMT val108/158met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiat. 58: 23-31, 2005. 2. Lee, S.-G., Joo, Y., Kim, B., Chung, S., Kim, H.-L., Lee, I., Choi, B., Kim, C., Song, K.Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116: 319-328, 2005.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    COMT (Catechol-O-Methyltransferase (COMT))

    Andere Bezeichnung

    COMT

    Hintergrund

    Synonyms: Catechol O-methyltransferase,2.1.1.6,COMT,

    Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes.

    Background: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

    Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.

    Molekulargewicht

    24 kDa, 28 kDa

    Gen-ID

    1312

    UniProt

    P21964

    Pathways

    Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interaktom
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