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COMT Antikörper (AA 52-271)

COMT Reaktivität: Human, Ratte, Maus WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043815
  • Target Alle COMT Antikörper anzeigen
    COMT (Catechol-O-Methyltransferase (COMT))
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 52-271
    Reaktivität
    • 56
    • 46
    • 39
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 64
    • 21
    • 3
    • 1
    Kaninchen
    Klonalität
    • 60
    • 29
    Polyklonal
    Konjugat
    • 58
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser COMT Antikörper ist unkonjugiert
    Applikation
    • 55
    • 36
    • 28
    • 24
    • 21
    • 12
    • 12
    • 9
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-COMT Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-COMT Antibody Picoband® (ABIN3043815). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human COMT recombinant protein (Position: G52-P271). Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product COMT Primärantikörper
  • Applikationshinweise
    Immunocytochemistry , 0.5-1 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
    Western blot, 0.1-0.5 μg/mL
    1. Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P., Skuse, D. COMT val108/158met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiat. 58: 23-31, 2005. 2. Lee, S.-G., Joo, Y., Kim, B., Chung, S., Kim, H.-L., Lee, I., Choi, B., Kim, C., Song, K.Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116: 319-328, 2005.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    COMT (Catechol-O-Methyltransferase (COMT))
    Andere Bezeichnung
    COMT (COMT Produkte)
    Hintergrund

    Synonyms: Catechol O-methyltransferase,2.1.1.6,COMT,

    Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes.

    Background: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

    Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.

    Molekulargewicht
    24 kDa, 28 kDa
    Gen-ID
    1312
    UniProt
    P21964
    Pathways
    Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interaktom
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