CCL1 Antikörper (AA 24-96)

Produktnummer ABIN3043738

Produktdetails anti-CCL1 Antikörper

Target: CCL1 (Chemokine (C-C Motif) Ligand 1 (CCL1))

Bindungsspezifität: AA 24-96

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Anti-I-309/CCL1 IGF1R Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-I-309/CCL1 IGF1R Antibody Picoband® (ABIN3043738). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human I-309 recombinant protein (Position: K24-K96). Human I-309 shares 38% amino acid (aa) sequence identity with mouse I-309.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, -
ELISA, 0.1-0.5 μg/mL, -
1. Miller, M. D., Wilson, S. D., Dorf, M. E., Seuanez, H. N., O'Brien, S. J., Krangel, M. S.Sequence and chromosomal location of the I-309 gene: relationship to genes encoding a family of inflammatory cytokines.J. Immun. 145: 2737-2744, 1990.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-CCL1 Antikörper (ABIN3043738)

Li, Chen, Liu, Hou: "Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway." in: World journal of gastroenterology, Vol. 22, Issue 23, pp. 5353-63, (2017) (PubMed).

Hou, Wan, Wang, Li, Wang, Yao, Feng, Jing, Lu, Jia, Peng: "Let-7a inhibits migration of melanoma cells via down-regulation of HMGA2 expression." in: American journal of translational research, Vol. 8, Issue 9, pp. 3656-3665, (2016) (PubMed).

Liang, Hao, Zhang, Wu, Wang: "Insulin-like growth factors in endometrioid adenocarcinoma: correlation with clinico-pathological features and estrogen receptor expression." in: BMC cancer, Vol. 12, pp. 262, (2013) (PubMed).

Zhang, Leng, Wang, Zhang: "Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome." in: Clinical orthopaedics and related research, Vol. 467, Issue 12, pp. 3175-82, (2010) (PubMed).

Details zu CCL1

Target: CCL1 (Chemokine (C-C Motif) Ligand 1 (CCL1))

Andere Bezeichnung: CCL1 (CCL1 Produkte)

Hintergrund:

Synonyms: Insulin-like growth factor 1 receptor,2.7.10.1,Insulin-like growth factor I receptor,IGF-I receptor,CD221,Insulin-like growth factor 1 receptor alpha chain,Insulin-like growth factor 1 receptor beta chain,IGF1R,

Tissue Specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. .

Background: CCL1, Chemokine (C-C motif) ligand 1, is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8.

Sequence Similarities: Belongs to the intercrine beta (chemokine CC) family.

Molekulargewicht: 11 kDa

Gen-ID: 6346

UniProt: P08069