HRH3 Antikörper (C-Term)

Produktnummer ABIN3043704

Produktdetails anti-HRH3 Antikörper

Target: HRH3 (Histamine Receptor H3 (HRH3))

Bindungsspezifität: AA 428-445, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Histamine H3 receptor(HRH3) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: CPQKLKIQPH SSLEHCWK

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Histamine H3 receptor(HRH3) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: histamine receptor H3
Protein Name: Histamine H3 receptor(H3R/HH3R)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human HRH3(428-445aa CPQKLKIQPHSSLEHCWK), different from the related rat sequence by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu HRH3

Target: HRH3 (Histamine Receptor H3 (HRH3))

Andere Bezeichnung: HRH3 (HRH3 Produkte)

Synonyme: GPCR97 antikoerper, HH3R antikoerper, AW049250 antikoerper, H3R antikoerper, histamine receptor H3 antikoerper, HRH3 antikoerper, Hrh3 antikoerper

Hintergrund: The histamine receptor H3(HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. And it shares 22 % and 21.4 % amino acid sequence homology with the H1(HRH1) and H2(HRH2) receptors, respectively. The expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Additionally, HRH3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle.

Synonyms: G protein coupled receptor 97 antibody|G-protein coupled receptor 97 antibody|GPCR 97 antibody|GPCR97 antibody|H3R antibody|HH 3R antibody|HH3 R antibody|HH3R antibody|Histamine H3 receptor antibody|Histamine receptor H3 antibody|HRH 3 antibody|HRH3 antibody|HRH3_HUMAN antibody|OTTHUMP00000031459 antibody

UniProt: Q9Y5N1

Pathways: cAMP Metabolic Process, Feeding Behaviour