PER2 Antikörper (AA 13-330)

Produktnummer ABIN3043602

Dieses Anti-PER2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PER2 in WB. Geeignet für Human.

Kurzübersicht für PER2 Antikörper (AA 13-330) (ABIN3043602)

Target: PER2 (Period Circadian Protein 2 (PER2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PER2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PER2 Antikörper

Bindungsspezifität: AA 13-330

Verwendungszweck: Anti-PER2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-PER2 Antibody Picoband® (ABIN3043602). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Chen, R., Schirmer, A., Lee, Y., Lee, H., Kumar, V., Yoo, S.-H., Takahashi, J. S., Lee, C. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Molec. Cell 36: 417-430, 2009. 2. Fu, L., Pelicano, H., Liu, J., Huang, P., Lee, C. C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41-50, 2002. Note: Erratum: 111: 1055 only, 2002. 3. Gery, S., Virk, R. K., Chumakov, K., Yu, A., Koeffler, H. P. The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene 26: 7916-7920, 2007.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Andere Bezeichnung: PER2

Hintergrund:

Synonyms: Period circadian protein homolog 2,hPER2,Circadian clock protein PERIOD 2,PER2,KIAA0347,

Tissue Specificity: Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). .

Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.

Molekulargewicht: 130 kDa

Gen-ID: 8864

UniProt: O15055