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PAX2A Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PAX2A in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 1 Publikation erwähnt.
Produktnummer ABIN3043591

Kurzübersicht für PAX2A Antikörper (C-Term) (ABIN3043591)

Target

Alle PAX2A Antikörper anzeigen
PAX2A (Paired Box Gene 2a (PAX2A))

Reaktivität

  • 83
  • 37
  • 24
  • 8
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 1
Human, Maus, Ratte

Wirt

  • 70
  • 17
Kaninchen

Klonalität

  • 62
  • 25
Polyklonal

Konjugat

  • 42
  • 8
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PAX2A Antikörper ist unkonjugiert

Applikation

  • 49
  • 41
  • 28
  • 13
  • 10
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 13
    • 8
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 248-282, C-Term

    Verwendungszweck

    Anti-Pax2 Antibody Picoband®

    Sequenz

    RKHLRADTFT QQQLEALDRV FERPSYPDVF QASEH

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-Pax2 Antibody Picoband® (ABIN3043591). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human Pax2, identical to the related mouse sequence.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Rat, Human
    1. "Entrez Gene: PAX2 paired box gene 2". 2. Pilz AJ, Povey S, Gruss P, Abbott CM (1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mamm. Genome 4 (2): 78-82. 3. Pfeffer, Peter L., Bernhard Payter, Gerlinde Reim, Marina Pasca di Magliano, Meinrad Busslinger (2001). "The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers". Development (133): 307-318.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yang, He, Peng, Zhong, Deng, Yu, Guan, Zuo, Xu: "Matrine suppresses the migration and invasion of NSCLC cells by inhibiting PAX2-induced epithelial-mesenchymal transition." in: OncoTargets and therapy, Vol. 10, pp. 5209-5217, (2017) (PubMed).

  • Target

    PAX2A (Paired Box Gene 2a (PAX2A))

    Andere Bezeichnung

    PAX2

    Hintergrund

    Synonyms: Paired box protein Pax-2,PAX2,

    Tissue Specificity: Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.

    Background: Paired box gene 2, also known as PAX2, is a protein which in humans is encoded by the PAX2 gene. This gene is mapped to 10q24. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

    Molekulargewicht

    45 kDa

    Gen-ID

    5076

    UniProt

    Q02962

    Pathways

    Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation
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