OTX2 Antikörper (C-Term)

Produktnummer ABIN3043586

Der Kaninchen Polyklonal Anti-OTX2-Antikörper wurde für WB validiert. Er ist geeignet, OTX2 in Proben von Human zu detektieren.

Kurzübersicht für OTX2 Antikörper (C-Term) (ABIN3043586)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-OTX2 Antikörper

Bindungsspezifität: AA 258-289, C-Term

Verwendungszweck: Anti-Otx2 Antibody Picoband®

Sequenz: DYKDQTASWK LNFNADCLDY KDQTSSWKFQ VL

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Otx2 Antibody Picoband® (ABIN3043586). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Otx2, identical to the related mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Bunt J, et al. OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels. Acta Neuropathol, 2013 Mar. 2. Gat-Yablonski G. Brain development is a multi-level regulated process--the case of the OTX2 gene. Pediatr Endocrinol Rev, 2011 Sep. 3. Liu Z, et al. Specific expression pattern of a novel Otx2 splicing variant during neural differentiation. Gene, 2013 Jul 1.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Andere Bezeichnung: OTX2

Hintergrund:

Synonyms: Homeobox protein OTX2,Orthodenticle homolog 2,OTX2,

Tissue Specificity: Expressed in brain.

Background: OTX2 is also known as CPHD6 or MCOPS5. This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Sequence Similarities: Belongs to the paired homeobox family. Bicoid subfamily.

Molekulargewicht: 32 kDa

Gen-ID: 5015

UniProt: P32243

Pathways: Dopaminergic Neurogenesis