DLG4 Antikörper (AA 581-724)

Produktnummer ABIN3043563

Produktdetails anti-DLG4 Antikörper

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Bindungsspezifität: AA 581-724

Reaktivität: Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Disks large homolog 4(DLG4) detection. Tested with WB, IHC-P in Human,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Disks large homolog 4(DLG4) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: discs, large homolog 4 (Drosophila)
Protein Name: Disks large homolog 4

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PSD95 recombinant protein (Position: H581-L724). Human PSD95 shares 100% amino acid (aa) sequence identity with both mouse and rat PSD95.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: DLG4 (DLG4 Produkte)

Synonyme: 11 antikoerper, CG1725 antikoerper, CG1730 antikoerper, CPD antikoerper, DLG antikoerper, DLG-A antikoerper, Discs-large antikoerper, Dlg antikoerper, Dlg-A antikoerper, Dlg1 antikoerper, DlgA antikoerper, Dmel\\CG1725 antikoerper, Drodlg antikoerper, PSD95 antikoerper, SAP97 antikoerper, anon-EST:Posey93 antikoerper, anon-WO03040301.258 antikoerper, anon-WO03040301.260 antikoerper, anon-WO03040301.268 antikoerper, d. lg.-1 antikoerper, dlg antikoerper, dlg-1 antikoerper, dlg-A antikoerper, dlgA antikoerper, dlgS97 antikoerper, l(1)10Bf antikoerper, l(1)G0276 antikoerper, l(1)G0342 antikoerper, l(1)G0456 antikoerper, l(1)G19 antikoerper, l(1)L11 antikoerper, l(1)bwn antikoerper, l(1)d.lg-1 antikoerper, l(1)d.lg.-1 antikoerper, l(1)discs large antikoerper, l(1)dlg antikoerper, l(1)dlg-1 antikoerper, l(1)dlg1 antikoerper, l(1)l.pr.-2 antikoerper, l(1)lpr-2 antikoerper, misb antikoerper, dlgh4 antikoerper, psd95 antikoerper, sap90 antikoerper, sap-90 antikoerper, LLGL1 antikoerper, Dlgh4 antikoerper, PSD-95 antikoerper, SAP90 antikoerper, SAP90A antikoerper, Sap90 antikoerper, SAP-90 antikoerper, DLG4 antikoerper, discs large 1 antikoerper, discs, large homolog 4 antikoerper, discs large MAGUK scaffold protein 4 antikoerper, discs, large homolog 4b (Drosophila) antikoerper, discs, large homolog 4 (Drosophila) antikoerper, dlg1 antikoerper, dlg4 antikoerper, DLG4 antikoerper, dlg4b antikoerper, Dlg4 antikoerper

Hintergrund: DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.

Synonyms: Discs large homolog 4 antibody|Disks large homolog 4 antibody|DLG 4 antibody|DLG4 antibody|DLG4_HUMAN antibody|FLJ97752 antibody| FLJ98574 antibody|Human post synaptic density protein 95 antibody|Human post-synaptic density protein 95 antibody|Post synaptic density protein 95 antibody|Postsynaptic density protein 95 antibody|PSD 95 antibody|PSD-95 antibody|PSD95 antibody|SAP 90 antibody| SAP-90 antibody|SAP90 antibody|Synapse associated protein 90 antibody|Synapse-associated protein 90 antibody|Tax interaction protein 15 antibody

Gen-ID: 1742

UniProt: P78352

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity