Ectodysplasin A Antikörper (AA 30-391)

Produktnummer ABIN3043548

Produktdetails anti-Ectodysplasin A Antikörper

Target: Ectodysplasin A (EDA)

Bindungsspezifität: AA 30-391

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ectodysplasin A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Anti-EDA Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-EDA Antibody Picoband® (ABIN3043548). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human EDA recombinant protein (Position: A30-S391). Human EDA shares 95% amino acid (aa) sequence identity with mouse EDA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Bayes, M., Hartung, A. J., Ezer, S., Pispa, J., Thesleff, I., Srivastava, A. K., Kere, J. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Molec. Genet. 7: 1661-1669, 1998. 2. Kere J, Srivastava AK, Montonen O, Zonana J, Thomas N, Ferguson B, Munoz F, Morgan D, Clarke A, Baybayan P, Chen EY, Ezer S, Saarialho-Kere U, de la Chapelle A, Schlessinger D (Sep 1996). "X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein". Nat Genet 13 (4): 409-16.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-Ectodysplasin A Antikörper (ABIN3043548)

Ning, Chen, Li, Wu, Wu, Li, Feng: "X-irradiation for inhibiting glial scar formation in injured spinal cord." in: Neural regeneration research, Vol. 8, Issue 17, pp. 1582-9, (2014) (PubMed).

Details zu Ectodysplasin A

Target: Ectodysplasin A (EDA)

Andere Bezeichnung: EDA (EDA Produkte)

Hintergrund:

Synonyms: Ectodysplasin-A,Ectodermal dysplasia protein,EDA protein,Ectodysplasin-A, membrane form,Ectodysplasin-A, secreted form,EDA,ED1, EDA2,

Tissue Specificity: Not abundant, expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. .

Background: Ectodysplasin-A is a protein that in humans is encoded by the EDA gene. It is mapped to Xq13.1. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.

Sequence Similarities: Belongs to the tumor necrosis factor family.

Molekulargewicht: 43 kDa

Gen-ID: 1896

UniProt: Q92838

Pathways: Tube Formation