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Ectodysplasin A Antikörper (AA 30-391)

Dieses Anti-Ectodysplasin A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Ectodysplasin A in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN3043548

Kurzübersicht für Ectodysplasin A Antikörper (AA 30-391) (ABIN3043548)

Target

Alle Ectodysplasin A (EDA) Antikörper anzeigen
Ectodysplasin A (EDA)

Reaktivität

  • 71
  • 55
  • 29
  • 10
  • 7
  • 7
  • 7
  • 7
  • 6
  • 6
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 68
  • 6
  • 1
Kaninchen

Klonalität

  • 66
  • 6
  • 2
Polyklonal

Konjugat

  • 28
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Ectodysplasin A Antikörper ist unkonjugiert

Applikation

  • 63
  • 35
  • 26
  • 26
  • 20
  • 12
  • 10
  • 6
  • 5
  • 3
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 16
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-391

    Verwendungszweck

    Anti-EDA Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-EDA Antibody Picoband® (ABIN3043548). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human EDA recombinant protein (Position: A30-S391). Human EDA shares 95% amino acid (aa) sequence identity with mouse EDA.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    1. Bayes, M., Hartung, A. J., Ezer, S., Pispa, J., Thesleff, I., Srivastava, A. K., Kere, J. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Molec. Genet. 7: 1661-1669, 1998. 2. Kere J, Srivastava AK, Montonen O, Zonana J, Thomas N, Ferguson B, Munoz F, Morgan D, Clarke A, Baybayan P, Chen EY, Ezer S, Saarialho-Kere U, de la Chapelle A, Schlessinger D (Sep 1996). "X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein". Nat Genet 13 (4): 409-16.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Ning, Chen, Li, Wu, Wu, Li, Feng: "X-irradiation for inhibiting glial scar formation in injured spinal cord." in: Neural regeneration research, Vol. 8, Issue 17, pp. 1582-9, (2014) (PubMed).

  • Target

    Ectodysplasin A (EDA)

    Andere Bezeichnung

    EDA

    Hintergrund

    Synonyms: Ectodysplasin-A,Ectodermal dysplasia protein,EDA protein,Ectodysplasin-A, membrane form,Ectodysplasin-A, secreted form,EDA,ED1, EDA2,

    Tissue Specificity: Not abundant, expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. .

    Background: Ectodysplasin-A is a protein that in humans is encoded by the EDA gene. It is mapped to Xq13.1. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.

    Sequence Similarities: Belongs to the tumor necrosis factor family.

    Molekulargewicht

    43 kDa

    Gen-ID

    1896

    UniProt

    Q92838

    Pathways

    Tube Formation
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