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SIRT6 Antikörper (AA 14-180)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIRT6 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN3043435

Kurzübersicht für SIRT6 Antikörper (AA 14-180) (ABIN3043435)

Target

Alle SIRT6 Antikörper anzeigen
SIRT6 (Sirtuin 6 (SIRT6))

Reaktivität

  • 93
  • 33
  • 19
  • 5
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 93
  • 14
  • 2
Kaninchen

Klonalität

  • 87
  • 22
Polyklonal

Konjugat

  • 61
  • 14
  • 6
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SIRT6 Antikörper ist unkonjugiert

Applikation

  • 89
  • 40
  • 34
  • 20
  • 18
  • 14
  • 14
  • 9
  • 7
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-180

    Verwendungszweck

    Anti-SIRT6 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-SIRT6 Antibody Picoband® (ABIN3043435). Tested in IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human SIRT6 recombinant protein (Position: D14-E180). Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse
    Western blot, 0.1-0.5 μg/mL, Human
    1. Kugel S, et al. Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci, 2014 Feb. 2. Takasaka N, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014 Feb 1. 3. Zhang ZG, et al. Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal regulated kinase signaling pathway. Mol Med Rep, 2014 Mar.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    SIRT6 (Sirtuin 6 (SIRT6))

    Andere Bezeichnung

    SIRT6

    Hintergrund

    Synonyms: NAD-dependent protein deacetylase sirtuin-6,3.5.1.-,Regulatory protein SIR2 homolog 6,SIR2-like protein 6,SIRT6,SIR2L6,

    Background: SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

    Sequence Similarities: Belongs to the sirtuin family. Class IV subfamily.

    Molekulargewicht

    39-42 kDa

    Gen-ID

    51548

    UniProt

    Q8N6T7
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