MMP1 Antikörper (Middle Region)

Produktnummer ABIN3043405

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MMP1 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 13+ Publikationen erwähnt.

Kurzübersicht für MMP1 Antikörper (Middle Region) (ABIN3043405)

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MMP1 Antikörper

Bindungsspezifität: AA 194-231, Middle Region

Verwendungszweck: Anti-MMP1 Antibody Picoband®

Sequenz: DAHFDEDERW TNNFREYNLH RVAAHELGHS LGLSHSTD

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-MMP1 Antibody Picoband® (ABIN3043405). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human MMP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Huang SF, Li YH, Ren YJ, Cao ZG, Long X (August 2008). "The effect of a single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter on force-induced MMP-1 expression in human periodontal ligament cells". Eur. J. Oral Sci. 116 (4): 319-23. 2. Pendás AM, Santamaría I, Alvarez MV, Pritchard M, López-Otín C (October 1996). "Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3". Genomics 37 (2): 266-8.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-MMP1 Antikörper (ABIN3043405)

Wendan, Changzhu, Xuhong, Hongjing, Hong, Dongxia, Fang: "BMSCs Interactions with Adventitial Fibroblasts Display Smooth Muscle Cell Lineage Potential in Differentiation and Migration That Contributes to Neointimal Formation." in: Stem cells international, Vol. 2016, pp. 3196071, (2016) (PubMed).

Zhang, Teng, Liu, Zhang, Liu: "Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 16, (2015) (PubMed).

Deng, Ling, Liu, Zhao, Lv: "Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 992-998, (2015) (PubMed).

Fan, Chen, Ni, Wang, Sun, Chen, Zheng: "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." in: OncoTargets and therapy, Vol. 8, pp. 1619-26, (2015) (PubMed).

Xu, Zhang, Xu, Guo, Wang, Wu, Wang, Luo, Zhou: "Antiphotoaging effect of conditioned medium of dedifferentiated adipocytes on skin in vivo and in vitro: a mechanistic study." in: Stem cells and development, Vol. 24, Issue 9, pp. 1096-111, (2015) (PubMed).

Zhang, Sun, Zhang, Ge, Liu, Zhao, Lu, Fan: "Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5?2 signaling pathway." in: BMC cancer, Vol. 14, pp. 193, (2014) (PubMed).

Zhu, Sun, Zhang, Liu, Li, Fan: "Norcantharidin enhances TIMP?2 anti?vasculogenic mimicry activity for human gallbladder cancers through downregulating MMP?2 and MT1?MMP." in: International journal of oncology, Vol. 46, Issue 2, pp. 627-40, (2014) (PubMed).

Yuan, Yang, Sun, Liu, Wang, Li, Man, Fu: "Effects of hydroxysafflor yellow A on proliferation and collagen synthesis of rat vascular adventitial fibroblasts induced by angiotensin II." in: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5772-81, (2014) (PubMed).

Man, Gao, Zhang, Liu, Yan, Huang, Liu: "Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma." in: Cancer biology & therapy, Vol. 11, Issue 6, pp. 592-8, (2011) (PubMed).

Liang, Pei, Zhang, Wang, Wang, Li: "The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats." in: Journal of food science, Vol. 75, Issue 8, pp. H230-8, (2011) (PubMed).

Zhang, Ding, Shi, Li, Haom, Ke, Tang: "Effects of exogenous urotensin II on vascular remodelling after balloon injury." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 4, pp. 477-81, (2010) (PubMed).

Liu, Ahmed, Nantajit, Rosenthal, Hai, Li: "Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats." in: International journal of molecular medicine, Vol. 19, Issue 6, pp. 865-73, (2007) (PubMed).

Yang, Xie, Geng, Luo, Han, Cheng: "Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats." in: World journal of gastroenterology, Vol. 11, Issue 32, pp. 4953-6, (2005) (PubMed).

Details zu MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Andere Bezeichnung: MMP1

Hintergrund:

Synonyms: Interstitial collagenase,3.4.24.7,Fibroblast collagenase,Matrix metalloproteinase-1,MMP-1,22 kDa interstitial collagenase,27 kDa interstitial collagenase,MMP1,CLG,

Tissue Specificity: Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart.

Background: Matrix metalloproteinase-1 (MMP-1), also known as interstitial collagenase and fibroblast collagenase, is an enzyme that in humans is encoded by the MMP1 gene. MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. It is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 54 kDa

Gen-ID: 4312

UniProt: P03956