PLD1 Antikörper (AA 1-330)

Produktnummer ABIN3043383

Dieses Anti-PLD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLD1 in WB. Geeignet für Human und Maus.

Kurzübersicht für PLD1 Antikörper (AA 1-330) (ABIN3043383)

Target: PLD1 (Phospholipase D1 (PLD1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLD1 Antikörper

Bindungsspezifität: AA 1-330

Verwendungszweck: Anti-Phospholipase D1/PLD1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Phospholipase D1/PLD1 Antibody Picoband® (ABIN3043383). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PLD1 recombinant protein (Position: M1-H330). Human PLD1 shares 91.8% and 90.9% amino acid (aa) sequence identity with mouse and rat PLD1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse
1. "Entrez Gene: PLD1 phospholipase D1, phosphatidylcholine-specific" 2. Colley, W. C., Altshuller, Y. M., Sue-Ling, C. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Branch, K. D., Tsirka, S. E., Bollag, R. J., Bollag, W. B., Frohman, M. A. Cloning and expression analysis of murine phospholipase D1. Biochem. J. 326: 745-753, 1997. 3. Park SH, Chun YH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD1 to human chromosome band 3q26 by fluorescence in situ hybridization". Cytogenet Cell Genet82 (3-4): 224.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu PLD1

Target: PLD1 (Phospholipase D1 (PLD1))

Andere Bezeichnung: PLD1

Hintergrund:

Synonyms: Phospholipase D1,PLD 1,hPLD1,3.1.4.4,Choline phosphatase 1,Phosphatidylcholine-hydrolyzing phospholipase D1,PLD1,

Tissue Specificity: Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. .

Background: By somatic cell hybrid analysis, PLD1 is mapped to 3q26.31. This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. And PLD1 disrupted association of gamma-secretase protein components, independent of PLD1catalytic activity. What's more, PLD1 regulates intracellular trafficking of beta-amyloid, distinct from its effect on gamma-secretase activity.

Sequence Similarities: Belongs to the phospholipase D family.

Molekulargewicht: 124 kDa

Gen-ID: 5337

UniProt: Q13393