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SMC3 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-SMC3-Antikörper wurde für WB und IHC validiert. Er ist geeignet, SMC3 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN3043343

Kurzübersicht für SMC3 Antikörper (C-Term) (ABIN3043343)

Target

Alle SMC3 Antikörper anzeigen
SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Reaktivität

  • 63
  • 25
  • 19
  • 8
  • 7
  • 7
  • 7
  • 5
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
Human, Maus, Ratte

Wirt

  • 58
  • 5
  • 1
Kaninchen

Klonalität

  • 51
  • 13
Polyklonal

Konjugat

  • 35
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SMC3 Antikörper ist unkonjugiert

Applikation

  • 36
  • 16
  • 13
  • 13
  • 13
  • 9
  • 8
  • 6
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 9
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1178-1216, C-Term

    Verwendungszweck

    Anti-SMC3 Antibody Picoband®

    Sequenz

    ELLESADKFY GVKFRNKVSH IDVITAEMAK DFVEDDTTH

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-SMC3 Antibody Picoband® (ABIN3043343). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human SMC3, identical to the related mouse sequence.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. "Entrez Gene: SMC3 structural maintenance of chromosomes 3". 2. Ghiselli G, Coffee N, Munnery CE, Koratkar R, Siracusa LD (2003). "The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway".J. Biol. Chem. 278 (22): 20259-67. 3. Patel CA, Ghiselli G (2005). "Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3". BMC Cell Biol. 6 (1): 3.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

    Andere Bezeichnung

    SMC3

    Hintergrund

    Synonyms: Structural maintenance of chromosomes protein 3,SMC protein 3,SMC-3,Basement membrane-associated chondroitin proteoglycan,Bamacan,Chondroitin sulfate proteoglycan 6,Chromosome-associated polypeptide,hCAP,SMC3,BAM, BMH, CSPG6, SMC3L1,

    Tissue Specificity: Predominantly expressed in the brain.

    Background: Structural maintenance of chromosomes 3, also known as SMC3, is a human gene. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

    Molekulargewicht

    140 kDa

    Gen-ID

    9126

    Pathways

    Stem Cell Maintenance
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