c-Rel Antikörper (Middle Region)
Kurzübersicht für c-Rel Antikörper (Middle Region) (ABIN3043314)
Target
Alle c-Rel Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- AA 268-306, Middle Region
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                                            Verwendungszweck
- Anti-c-Rel Antibody Picoband®
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                                            Sequenz
- DQEVSESMDF RYLPDEKDAY GNKSKKQKTT LIFQKLLQD
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                                            Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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                                            Produktmerkmale
- Anti-c-Rel Antibody Picoband® (ABIN3043314). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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                                            Aufreinigung
- Immunogen affinity purified.
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                                            Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of mouse c-Rel, different from the related human sequence by four amino acids.
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                                            Isotyp
- IgG
 
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    - 
                                            Applikationshinweise
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                        Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
 Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
 1. Belguise, K., Sonenshein, G. E. PKC-theta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor-alpha synthesis. J. Clin. Invest. 117: 4009-4021, 2007. 2. Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene 23 (13): 2275-86. 3. Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev 6 (5): 745-60.
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                                            Kommentare
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                        Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P). 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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    - 
                                            Format
- Lyophilized
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                                            Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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                                            Konzentration
- 500 μg/mL
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                                            Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Handhabung
- Avoid repeated freezing and thawing.
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                                            Lagerung
- 4 °C,-20 °C
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                                            Informationen zur Lagerung
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                        Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. 
 It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
 
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    - c-Rel (REL proto-oncogene (c-Rel))
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                                            Andere Bezeichnung
- Rel
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                                            Hintergrund
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                        Synonyms: Proto-oncogene c-Rel,Rel, Tissue Specificity: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. . Background: The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. This gene is mapped to chromosome 2p13-p12. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma. 
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                                            Molekulargewicht
- 69 kDa
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                                            Gen-ID
- 19696
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                                            UniProt
- P15307
 Target
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