ITGA5 Antikörper (AA 787-992)

Produktnummer ABIN3043256

Der Kaninchen Polyklonal Anti-ITGA5-Antikörper wurde für WB validiert. Er ist geeignet, ITGA5 in Proben von Human, Maus und Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für ITGA5 Antikörper (AA 787-992) (ABIN3043256)

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ITGA5 Antikörper

Bindungsspezifität: AA 787-992

Verwendungszweck: Anti-Integrin alpha 5/ITGA5 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Integrin alpha 5/ITGA5 Antibody Picoband® (ABIN3043256). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Integrin alpha 5 recombinant protein (Position: E787-E992). Human Integrin alpha 5 shares 86% amino acid (aa) sequence identity with mouse Integrin alpha 5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). 2. "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)"

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-ITGA5 Antikörper (ABIN3043256)

Chen, Sun, Liu, Tong, Meng: "Silencing of Paternally Expressed Gene 10 Inhibits Trophoblast Proliferation and Invasion." in: PLoS ONE, Vol. 10, Issue 12, pp. e0144845, (2015) (PubMed).

Zhang, Ren, Luo, Fan, Liu, Liang, Ma, Yu, Bai: "A small physiological electric field mediated responses of extravillous trophoblasts derived from HTR8/SVneo cells: involvement of activation of focal adhesion kinase signaling." in: PLoS ONE, Vol. 9, Issue 3, pp. e92252, (2014) (PubMed).

Huang, Lian, Chen, Yang, Yang: "Characterization of rat hair follicle stem cells selected by vario magnetic activated cell sorting system." in: Acta histochemica et cytochemica, Vol. 42, Issue 5, pp. 129-36, (2009) (PubMed).

Details zu ITGA5

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Andere Bezeichnung: ITGA5

Hintergrund:

Synonyms: Integrin alpha-5,CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5,CD49e,Integrin alpha-5 heavy chain,Integrin alpha-5 light chain,ITGA5,FNRA,

Tissue Specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland. .

Background: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Sequence Similarities: Belongs to the integrin alpha chain family.

Molekulargewicht: 130 kDa

Gen-ID: 3678

UniProt: P08648

Pathways: Integrin Complex