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HYAL2 Antikörper (C-Term)

Dieses Anti-HYAL2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HYAL2 in WB. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN3043041

Kurzübersicht für HYAL2 Antikörper (C-Term) (ABIN3043041)

Target

Alle HYAL2 Antikörper anzeigen
HYAL2 (Hyaluronidase-2 (HYAL2))

Reaktivität

  • 51
  • 28
  • 4
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 57
  • 2
Kaninchen

Klonalität

  • 59
Polyklonal

Konjugat

  • 22
  • 7
  • 6
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HYAL2 Antikörper ist unkonjugiert

Applikation

  • 51
  • 27
  • 25
  • 13
  • 13
  • 11
  • 8
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 142-157, C-Term

    Verwendungszweck

    Anti-Hyaluronidase-2 HYAL2 Antibody Picoband®

    Sequenz

    VRNWQDKDVY RRLSRQ

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Hyaluronidase-2 HYAL2 Antibody (ABIN3043041). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2, different from the related mouse and rat sequences by three amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Lepperdinger, G., Strobl, B., Kreil, G. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. J. Biol. Chem. 273: 22466-22470, 1998. 2. Rai, S. K., Duh, F.-M., Vigdorovich, V., Danilkovitch-Miagkova, A., Lerman, M. I., Miller, A. D. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc. Nat. Acad. Sci. 98: 4443-4448, 2001. 3. Strobl, B., Wechselberger, C., Beier, D. R., Lepperdinger, G. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics 53: 214-219, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    HYAL2 (Hyaluronidase-2 (HYAL2))

    Andere Bezeichnung

    HYAL2

    Hintergrund

    Synonyms: Hyaluronidase-2;Hyal-2;3.2.1.35;Hyaluronoglucosaminidase-2;Lung carcinoma protein 2;LuCa-2;HYAL2;LUCA2;

    Tissue Specificity: Widely expressed. No expression detected in adult brain. .

    Background: HYAL2 (hyaluronoglucosaminidase 2) also known as hyaluronidase 2, LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that HYAL2 was expressed in all human tissues tested except adult brain, and Western blot analysis detected Hyal2protein in all mouse tissues examined except adult brain. The HYAL2 gene is mapped on 3p21.31. HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus (JSRV). The findings of Rai et al. (2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.

    Sequence Similarities: Belongs to the glycosyl hydrolase 56 family.

    Molekulargewicht

    54 kDa

    UniProt

    Q12891

    Pathways

    Transition Metal Ion Homeostasis, Glycosaminoglycan Metabolic Process
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