CXCR2 Antikörper (Middle Region)

Produktnummer ABIN3043018

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CXCR2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Ratte. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für CXCR2 Antikörper (Middle Region) (ABIN3043018)

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CXCR2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-CXCR2 Antibody

Sequenz: CYEDMGNNTA NWRMLLR

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse sequence by six amino acids.

Produktmerkmale: Anti-CXCR2 Antibody. Tested in WB applications. This antibody reacts with Human, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CXCR2, different from the related mouse sequence by six amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CXCR2 Antikörper (ABIN3043018)

Zhou, Li, Li, Liu, Zhu, Ju, Miao, Xu: "Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion." in: Molecular pain, Vol. 12, (2016) (PubMed).

Xu, Zhu, Zhang, Tian, Zhang, Wu, Gao: "NF?B-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice." in: Journal of neuroinflammation, Vol. 11, pp. 38, (2014) (PubMed).

Cao, Zhang, Xie, Jiang, Ji, Gao: "Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2." in: Experimental neurology, Vol. 261, pp. 328-36, (2014) (PubMed).

Chen, Park, Xie, Berta, Nedergaard, Ji: "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice." in: Brain : a journal of neurology, Vol. 137, Issue Pt 8, pp. 2193-209, (2014) (PubMed).

Zhang, Cao, Zhang, Ji, Gao: "Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons." in: Pain, Vol. 154, Issue 10, pp. 2185-97, (2013) (PubMed).

Details zu CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Andere Bezeichnung: CXCR2

Hintergrund:

Background: CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

Gene Full Name: C-X-C motif chemokine receptor 2

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Molekulargewicht: 45 kDa

Gen-ID: 3579

UniProt: P25025

Pathways: cAMP Metabolic Process