HSC70 Interacting Protein HIP Antikörper (N-Term)

Produktnummer ABIN3042991

Produktdetails anti-HSC70 Interacting Protein HIP Antikörper

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Bindungsspezifität: AA 1-19, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSC70 Interacting Protein HIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Hsc70-interacting protein(ST13) detection. Tested with WB in Human.

Sequenz: MDPRKVNELR AFVKMCKQD

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Hsc70-interacting protein(ST13) detection. Tested with WB in Human.
Gene Name: suppression of tumorigenicity 13(colon carcinoma)(Hsp70 interacting protein)
Protein Name: Hsc70-interacting protein

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ST13(1-19aa MDPRKVNELRAFVKMCKQD), different from the related rat and mouse sequences by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu HSC70 Interacting Protein HIP

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Andere Bezeichnung: ST13 (ST13 Produkte)

Synonyme: CG32789 antikoerper, Dmel\\CG32789 antikoerper, anon-EST:fe1A9 antikoerper, 1110007I03Rik antikoerper, 3110002K08Rik antikoerper, AW555194 antikoerper, HIP antikoerper, HOP antikoerper, HSPABP antikoerper, HSPABP1 antikoerper, PRO0786 antikoerper, SNC6 antikoerper, p48 antikoerper, AAG2 antikoerper, FAM10A1 antikoerper, FAM10A4 antikoerper, P48 antikoerper, Hsc/Hsp70-interacting protein antikoerper, suppression of tumorigenicity 13 antikoerper, ST13, Hsp70 interacting protein antikoerper, suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) antikoerper, HIP antikoerper, St13 antikoerper, ST13 antikoerper

Hintergrund: ST13(Suppression of Tumorigenicity 13), also known as P48 or HIP, is a protein that in humans is encoded by the ST13 gene. ST13 is an abundant, highly conserved protein that binds the major cytosolic chaperones heat-shock protein 70-kD(HSP70) and HSP90 during an intermediate stage of steroid receptor assembly, but is absent from the mature receptor complex. Zhang et al.(1998) mapped the ST13 gene to chromosome 22q13 by fluorescence in situ hybridization. They noted that colorectal, breast, and ovarian carcinomas frequently show loss of heterozygosity at this site. Using a yeast 2-hybrid assay, Hohfeld et al.(1995) showed that rat Hip bound Hsc70(HSPA8). One Hip oligomer bound the ATPase domains of at least 2 Hsc70 Molecules, and binding was dependent on activation of the Hsc70 ATPase by Hsp40(DNAJB1). Hip stabilized the ADP-bound form of Hsc70, which had a high affinity for a test protein substrate. Hohfeld et al.(1995) concluded that HIP contributes to interactions of HSC70 with target proteins through its own chaperone activity.

Synonyms: AAG 2 antibody|AAG2 antibody|Aging associated protein 2 antibody|F10A1_HUMAN antibody|FAM10A1 antibody|FAM10A4 antibody|FLJ27260 antibody|Heat shock 70kD protein binding protein antibody|HIP antibody|HOP antibody|Hsc70 interacting protein antibody|Hsc70-interacting protein antibody|Hsp70 interacting protein antibody|HSPABP 1 antibody|HSPABP antibody|HSPABP1 antibody|MGC129952 antibody|OTTHUMP00000028873 antibody|P48 antibody|PRO0786 antibody|Progesterone receptor associated p48 protein antibody|Progesterone receptor-associated p48 protein antibody|Protein FAM10A1 antibody|Putative tumor suppressor ST13 antibody|Renal carcinoma antigen NY REN 33 antibody|Renal carcinoma antigen NY-REN-33 antibody|SNC 6 antibody|SNC6 antibody|ST 13 antibody|ST13 antibody|Suppression of tumorigenicity 13 antibody|Suppression of tumorigenicity 13(colon carcinoma) antibody|Suppression of tumorigenicity 13 protein antibody|Suppression of tumorigenicity protein 13 antibody

UniProt: P50502