CXCR5 Antikörper (C-Term)

Produktnummer ABIN3042947

Der Kaninchen Polyklonal Anti-CXCR5-Antikörper wurde für WB validiert. Er ist geeignet, CXCR5 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CXCR5 Antikörper (C-Term) (ABIN3042947)

Target: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CXCR5 Antikörper

Bindungsspezifität: AA 358-372, C-Term

Verwendungszweck: Anti-CXCR5 Antibody Picoband®

Sequenz: SSLSESENAT SLTTF

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-CXCR5 Antibody (ABIN3042947). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CXCR5, identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Allen, C. D. C., Ansel, K. M., Low, C., Lesley, R., Tamamura, H., Fujii, N., Cyster, J. G. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nature Immun. 5: 943-952, 2004. 2. Chan, C.-C., Shen, D., Hackett, J. J., Buggage, R. R., Tuaillon, N. Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma. Ophthalmology 110: 421-426, 2003. 3. Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Forster, R., Cyster, J. G. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416: 94-99, 2002.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CXCR5

Target: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Andere Bezeichnung: CXCR5

Hintergrund:

Synonyms: C-X-C chemokine receptor type 5,CXC-R5,CXCR-5,Burkitt lymphoma receptor 1,Monocyte-derived receptor 15,MDR-15,CD185,CXCR5,BLR1, MDR15,

Tissue Specificity: Expression in mature B-cells and Burkitt lymphoma cells.

Background: CXCR5 (Chemokine CXC Motif Receptor 5), also known as BLR1, is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene. The gene plays an essential role in B cell migration. Reif et al. (2002) concluded that their findings defined the mechanism of B-cell relocalization in response to antigen, and established that cell position in vivo can be determined by the balance of responsiveness to chemoattractants made in separate but adjacent zones. Chan et al. (2003) investigated the expression of chemokines and chemokine receptors in eyes with primary intraocular B-cell lymphoma (PIOL).

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Molekulargewicht: 22 kDa

UniProt: P32302