SDC3 Antikörper (N-Term)

Produktnummer ABIN3042886

Produktdetails anti-SDC3 Antikörper

Target: SDC3 (Syndecan 3 (SDC3))

Bindungsspezifität: AA 45-60, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SDC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: Anti-Syndecan 3/SDC3 Antibody Picoband®

Sequenz: AQRWRNENFE RPVDLE

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Syndecan 3/SDC3 Antibody (ABIN3042886). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Syndecan 3/SDC3, identical to the related rat sequence, and different from the related human sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Berndt, C., Casaroli-Marano, R. P., Vilaro, S., Reina, M. Cloning and characterization of human syndecan-3. J. Cell. Biol. 82: 246-259, 2001. 2. Bobardt, M. D., Saphire, A. C. S., Hung, H.-C., Yu, X., Van der Schueren, B., Zhang, Z., David, G., Gallay, P. A. Syndecan captures, protects, and transmits HIV to T lymphocytes. Immunity 18: 27-39, 2003. 3. de Witte, L., Bobardt, M., Chatterji, U., Degeest, G., David, G., Geijtenbeek, T. B. H., Gallay, P. Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.Proc. Nat. Acad. Sci. 104: 19464-19469, 2007. 4. Ha, E., Kim, M.-J., Choi, B.-K., Rho, J.-J., Oh, D.-J., Rho, T.-H., Kim, K.-H., Lee, H. J., Shin, D.-H., Yim, S. V., Baik, H. H., Chung, J.-H., Kim, J. W. Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population. J. Clin. Endocr. Metab. 91: 5095-5099, 2006.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SDC3 Antikörper (ABIN3042886)

Yao, Zhang, Huang, Li, Gao: "Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer." in: World journal of gastroenterology, Vol. 23, Issue 21, pp. 3907-3914, (2017) (PubMed).

Yao, Li, Li, Feng, Gao: "Midkine promotes perineural invasion in human pancreatic cancer." in: World journal of gastroenterology, Vol. 20, Issue 11, pp. 3018-24, (2014) (PubMed).

Details zu SDC3

Target: SDC3 (Syndecan 3 (SDC3))

Andere Bezeichnung: SDC3 (SDC3 Produkte)

Hintergrund:

Synonyms: Syndecan-3,SYND3,Sdc3,Kiaa0468,

Tissue Specificity: Expressed in most tissues. Most abundant in kidney, bone and liver.

Background: Syndecan-3, also called SYND3 is a protein that in humans is encoded by the SDC3 gene. This gene was assigned to human chromosome 1p35.2. This gene can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparin sulfate chains. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, and possibly by transferring signals from the cell surface in a sugar-dependent mechanism. In wildtype mice, SDC3 was expressed in hypothalamic regions that control energy balance. It was proposed that oscillation of hypothalamic SDC3 levels physiologically modulates feeding behavior.

Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Molekulargewicht: 60 kDa

UniProt: Q64519

Pathways: Glycosaminoglycan Metabolic Process