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ITGA7 Antikörper (C-Term)

ITGA7 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3042822
  • Target Alle ITGA7 Antikörper anzeigen
    ITGA7 (Integrin, alpha 7 (ITGA7))
    Bindungsspezifität
    • 11
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1123-1139, C-Term
    Reaktivität
    • 43
    • 17
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 39
    • 7
    • 1
    Kaninchen
    Klonalität
    • 40
    • 7
    Polyklonal
    Konjugat
    • 28
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITGA7 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 20
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Anti-Integrin alpha-7 ITGA7 Antibody Picoband®
    Sequenz
    HAVKIPREDR QQFKEEK
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Integrin alpha-7 ITGA7 Antibody (ABIN3042822). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human ITGA7, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product ITGA7 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. Guo, C., Willem, M., Werner, A., Raivich, G., Emerson, M., Neyses, L., Mayer, U. Absence of alpha-7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Hum. Molec. Genet. 15: 989-998, 2006. 2. Nawrotzki, R., Willem, M., Miosge, N., Brinkmeier, H., Mayer, U. Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice. Hum. Molec. Genet. 12: 483-495, 2003.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Zhang, Teng, Liu, Zhang, Liu: "Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 16, (2015) (PubMed).

  • Target
    ITGA7 (Integrin, alpha 7 (ITGA7))
    Andere Bezeichnung
    ITGA7 (ITGA7 Produkte)
    Hintergrund

    Synonyms: Integrin alpha-7,Integrin alpha-7 heavy chain,Integrin alpha-7 light chain,Integrin alpha-7 70 kDa form,ITGA7,UNQ406/PRO768,

    Tissue Specificity: Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions, isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle. .

    Background: Integrin alpha-7 is a protein that in humans is encoded by the ITGA7 gene. This gene is mapped to 12q13.2. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy.

    Sequence Similarities: Belongs to the integrin alpha chain family.

    Molekulargewicht
    33 kDa
    UniProt
    Q13683
    Pathways
    Integrin Complex
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