CREB3L1 Antikörper (AA 1-204)

Produktnummer ABIN3042759

Dieses Anti-CREB3L1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CREB3L1 in WB. Geeignet für Human.

Kurzübersicht für CREB3L1 Antikörper (AA 1-204) (ABIN3042759)

Target: CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CREB3L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CREB3L1 Antikörper

Bindungsspezifität: AA 1-204

Verwendungszweck: Anti-CREB3L1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-CREB3L1 Antibody Picoband® (ABIN3042759). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CREB3L1 recombinant protein (Position: M1-M204). Human CREB3L1 shares 93.6% and 93.1% amino acid (aa) sequence identity with mouse and rat CREB3L1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Denard B, Lee C, Ye J. ""Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1"". Elife, 2012 Dec 18. 2. Mellor P, Deibert L, Calvert B, Bonham K, Carlsen SA, Anderson DH. ""CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis"". Mol Cell Biol, 2013 Dec.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu CREB3L1

Target: CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))

Andere Bezeichnung: CREB3L1

Hintergrund:

Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 1,cAMP-responsive element-binding protein 3-like protein 1,Old astrocyte specifically-induced substance,OASIS,Processed cyclic AMP-responsive element-binding protein 3-like protein 1,CREB3L1,OASIS,PSEC0238,

Tissue Specificity: Expressed in several tissues, with highest levels in pancreas and prostate. Expressed at relatively lower levels in brain. .

Background: CREB3L1, known as Cyclic AMP-responsive element-binding protein 3-like protein 1, is mapped to 11p11.2. The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements.

Sequence Similarities: Belongs to the bZIP family. ATF subfamily.

Molekulargewicht: 57 kDa

Gen-ID: 90993

Pathways: Thyroid Hormone Synthesis, Chromatin Binding