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Caveolin 2 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-Caveolin 2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Caveolin 2 in Proben von Human, Maus und Ratte zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN3042683

Kurzübersicht für Caveolin 2 Antikörper (N-Term) (ABIN3042683)

Target

Alle Caveolin 2 (CAV2) Antikörper anzeigen
Caveolin 2 (CAV2)

Reaktivität

  • 74
  • 40
  • 39
  • 6
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 78
  • 10
  • 2
  • 1
Kaninchen

Klonalität

  • 71
  • 20
Polyklonal

Konjugat

  • 38
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser Caveolin 2 Antikörper ist unkonjugiert

Applikation

  • 54
  • 26
  • 18
  • 16
  • 14
  • 13
  • 13
  • 9
  • 7
  • 6
  • 4
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 10
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-17, N-Term

    Verwendungszweck

    Anti-Caveolin-2/CAV2 Antibody Picoband®

    Sequenz

    MGLETEKADV QLFMDDD

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Caveolin-2/CAV2 Antibody (ABIN3042683). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human Caveolin-2, different from the related rat and mouse sequences by one amino acid.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Scherer, P. E., Okamoto, T., Chun, M., Nishimoto, I., Lodish, H. F., Lisanti, M. P.Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.Proc. Nat. Acad. Sci. 93: 131-135, 1996. 2. Yamazaki, K., Mizui, Y., Tanaka, I.Radiation hybrid mapping of human ADAM10 gene to chromosome 15.Genomics 45: 457-459, 1997. 2. Galbiati, F., Volonte, D., Gil, O., Zanazzi, G., Salzer, J. L., Sargiacomo, M., Scherer, P. E., Engelman, J. A., Schlegel, A., Parenti, M., Okamoto, T., Lisanti, M. P.Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury.Proc. Nat. Acad. Sci. 95: 10257-10262, 1998. 3. Engelman, J. A., Zhang, X. L., Galbiati, F., Lisanti, M. P.Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3): Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31).FEBS Lett. 429: 330-336, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: "Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 14, Issue 9, pp. 4983-8, (2013) (PubMed).

  • Target

    Caveolin 2 (CAV2)

    Andere Bezeichnung

    CAV2

    Hintergrund

    Synonyms: Caveolin-2,CAV2,

    Tissue Specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. .

    Background: Caveolin-2 is a protein related to caveolin-1 which is derived caveolin-enriched membranes. CAV2 and CAV1 are similar in most respects and they differ in their functional interactions with heterotrimeric G proteins. Caveolin-1 and caveolin-2 are expressed in neuronal cells. Caveolin-2 was upregulated in response to neuronal cell injury. The CAV2 gene is mapped to 7q31.1-q31.2. The CAV1 gene contains 3 exons, while the human CAV2 gene contains 2 exons. The boundary of the last exon of CAV1 and CAV2 are analogous, suggesting that they arose through gene duplication. The genes encoding murine caveolin-1 and -2 are colocalized within the A2 region of mouse chromosome 6.

    Sequence Similarities: Belongs to the caveolin family.

    Molekulargewicht

    17 kDa

    UniProt

    P51636

    Pathways

    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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