RGS Antikörper (C-Term)

Produktnummer ABIN3042642

Dieses Anti-RGS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RGS in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RGS Antikörper (C-Term) (ABIN3042642)

Target: RGS (Regulator of G-Protein Signaling 9 (RGS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RGS Antikörper

Bindungsspezifität: AA 624-638, C-Term

Verwendungszweck: Anti-RGS9 Antibody Picoband®

Sequenz: LKSKRVANFF QIKMD

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-RGS9 Antibody (ABIN3042642). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RGS9, different from the related mouse and rat sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Cabrera-Vera, T. M., Hernandez, S., Earls, L. R., Medkova, M., Sundgren-Andersson, A. K., Surmeier, D. J., Hamm, H. E. RGS9-2 modulates D2 dopamine receptor-mediated Ca(2+) channel inhibition in rat striatal cholinergic interneurons. Proc. Nat. Acad. Sci. 101: 16339-16344, 2004. 2. Hu, G., Zhang, Z., Wensel, T. G. Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. J. Biol. Chem. 278: 14550-14554, 2003. 3. Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A., Wilkie, T. M. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RGS

Target: RGS (Regulator of G-Protein Signaling 9 (RGS))

Andere Bezeichnung: RGS9

Hintergrund:

Synonyms: Regulator of G-protein signaling 9,RGS9,RGS9,

Tissue Specificity: Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

Background: Regulator of G-protein signaling 9, also known as RGS9 is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. This gene is mapped to 17q24.1. This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.

Sequence Similarities: Contains 1 DEP domain.

Molekulargewicht: 56 kDa, 77 kDa

UniProt: O75916

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction