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P-Cadherin Antikörper (Middle Region)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch P-Cadherin in WB, IHC und ICC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN3042613

Kurzübersicht für P-Cadherin Antikörper (Middle Region) (ABIN3042613)

Target

Alle P-Cadherin (CDH3) Antikörper anzeigen
P-Cadherin (CDH3)

Reaktivität

  • 106
  • 52
  • 8
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Human

Wirt

  • 96
  • 21
  • 2
  • 2
Kaninchen

Klonalität

  • 96
  • 23
  • 1
Polyklonal

Konjugat

  • 55
  • 12
  • 11
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser P-Cadherin Antikörper ist unkonjugiert

Applikation

  • 101
  • 54
  • 41
  • 36
  • 27
  • 19
  • 16
  • 15
  • 13
  • 13
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 16
    • 9
    • 8
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 612-626, Middle Region

    Verwendungszweck

    Anti-P-Cadherin-3 CDH3-Antibody Picoband®

    Sequenz

    QDTYDVHLSL SDHGN

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-P-Cadherin-3 CDH3-Antibody (ABIN3042613). Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human P cadherin, different from the mouse and rat sequences by one amino acid.

    Isotyp

    IgG
  • Applikationshinweise

    Immunocytochemistry , 0.5-1 μg/mL, Human, -
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Dec 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488-90.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    P-Cadherin (CDH3)

    Andere Bezeichnung

    CDH3

    Hintergrund

    Synonyms: Cadherin-3,Placental cadherin,P-cadherin,CDH3,CDHP,

    Tissue Specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines. .

    Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

    Sequence Similarities: Contains 5 cadherin domains.

    Molekulargewicht

    120 kDa

    UniProt

    P22223
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