EPB41L1 Antikörper (C-Term)

Produktnummer ABIN3042566

Der Kaninchen Polyklonal Anti-EPB41L1-Antikörper wurde für WB validiert. Er ist geeignet, EPB41L1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für EPB41L1 Antikörper (C-Term) (ABIN3042566)

Target: EPB41L1 (erythrocyte Membrane Protein Band 4.1-Like 1 (EPB41L1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPB41L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EPB41L1 Antikörper

Bindungsspezifität: AA 585-604, C-Term

Verwendungszweck: Anti-Band 4.1-like protein 1 EPB41L1 Antibody Picoband®

Sequenz: QDQERDTVFL KDNHLAIERK

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Band 4.1-like protein 1 EPB41L1 Antibody (ABIN3042566). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human EPB41L1, different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1. Binda, Alicia V, Kabbani Nadine, Lin Ridwan, Levenson Robert (September 2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Mol. Pharmacol. (United States) 62 (3): 507-13. 2. Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., Tomitori, H., Daoud, H., and 22 others. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am. J. Hum. Genet. 88: 306-316, 2011. Note: Erratum: Am. J. Hum. Genet. 88: 516 only, 2011. 3. Kim AC, Van Huffel C, Lutchman M, Chishti AH (June 1998). "Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12". Genomics 49 (1): 165-6.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu EPB41L1

Target: EPB41L1 (erythrocyte Membrane Protein Band 4.1-Like 1 (EPB41L1))

Andere Bezeichnung: EPB41L1

Hintergrund:

Synonyms: Band 4.1-like protein 1,Neuronal protein 4.1,4.1N,EPB41L1,KIAA0338,

Tissue Specificity: Highest expression in brain, lower in heart, kidney, pancreas, placenta, lung and skeletal muscle.

Background: Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene. This gene is mapped to 20q11.23. It is found that a heterozygous missense mutation in the EPB41L1 gene causing nonsyndromic intellectual disability. This gene may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. EPB41L1 has been shown to interact with ITPR1, Dopamine receptor D2, Dopamine receptor D3, CENTG1 and Nuclear mitotic apparatus protein 1.

Sequence Similarities: Contains 1 FERM domain.

Molekulargewicht: 99 kDa

UniProt: Q9H4G0