ST5 Antikörper (Middle Region)

Produktnummer ABIN3042548

Der Kaninchen Polyklonal Anti-ST5-Antikörper wurde für WB validiert. Er ist geeignet, ST5 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ST5 Antikörper (Middle Region) (ABIN3042548)

Target: ST5 (Suppression of Tumorigenicity 5 (ST5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ST5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ST5 Antikörper

Bindungsspezifität: AA 571-586, Middle Region

Verwendungszweck: Anti-ST5 Antibody Picoband®

Sequenz: KRHSHDDMLL LAQLSL

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-ST5 Antibody (ABIN3042548). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human ST5, different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: ST5 suppression of tumorigenicity 5" 2. Lichy JH, Modi WS, Seuanez HN, Howley PM (Nov 1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells".Cell Growth Differ 3 (8): 541-8. 3. Trautmann, U., Vikkula, M., Winterpacht, A., FitzPatrick, D. R., Rauch, A. Disruption of ST5 is associated with mental retardation and multiple congenital abnormalities. J. Med. Genet. 47: 91-98, 2010.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu ST5

Target: ST5 (Suppression of Tumorigenicity 5 (ST5))

Andere Bezeichnung: ST5

Hintergrund:

Synonyms: Suppression of tumorigenicity 5 protein,DENN domain-containing protein 2B,HeLa tumor suppression 1,ST5,DENND2B, HTS1,

Tissue Specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). .

Background: Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene. This gene is mapped to 11p15.4. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.

Sequence Similarities: Contains 1 dDENN domain.

Molekulargewicht: 126 kDa

UniProt: P78524