LOX Antikörper (Middle Region)

Produktnummer ABIN3042506

Der Kaninchen Polyklonal Anti-LOX-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, LOX in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für LOX Antikörper (Middle Region) (ABIN3042506)

Target: LOX (Lysyl Oxidase (LOX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-LOX Antikörper

Bindungsspezifität: AA 240-268, Middle Region

Verwendungszweck: Anti-LOX Antibody Picoband®

Sequenz: AEENCLASTA YRADVRDYDH RVLLRFPQR

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-LOX Antibody Picoband® (ABIN3042506). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human LOX, different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Hamalainen, E.-R., Jones, T. A., Sheer, D., Taskinen, K., Pihlajaniemi, T., Kivirikko, K. I. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. Genomics 11: 508-516, 1991. 2. Kuivaniemi, H., Savolainen, E.-R., Kivirikko, K. I. Human placental lysyl oxidase: purification, partial characterization, and preparation of two specific antisera to the enzyme. J. Biol. Chem. 259: 6996-7002, 1984.  3. Li, W., Nellaiappan, K., Strassmaier, T., Graham, L., Thomas, K. M., Kagan, H. M. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Proc. Nat. Acad. Sci. 94: 12817-12822, 1997.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu LOX

Target: LOX (Lysyl Oxidase (LOX))

Andere Bezeichnung: LOX

Hintergrund:

Synonyms: Protein-lysine 6-oxidase;1.4.3.13;Lysyl oxidase;LOX;

Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. .

Background: Lysyl oxidase  (LOX), also known as protein-lysine 6-oxidase, is a protein that, in humans, is encoded by the LOX gene. The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. 

Molekulargewicht: 31 kDa

Gen-ID: 4015

UniProt: P28300

Pathways: SARS-CoV-2 Protein Interaktom