Otoferlin Antikörper (C-Term)

Produktnummer ABIN3042499

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Otoferlin in IHC und WB. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für Otoferlin Antikörper (C-Term) (ABIN3042499)

Target: Otoferlin (OTOF)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Otoferlin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-Otoferlin Antikörper

Bindungsspezifität: AA 1831-1863, C-Term

Verwendungszweck: Anti-Otoferlin Antibody

Sequenz: QIWDADHFSA DDFLGAIELD LNRFPRGAKT AKQ

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Otoferlin Antibody (ABIN3042499). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Otoferlin, identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Otoferlin

Target: Otoferlin (OTOF)

Andere Bezeichnung: OTOF

Hintergrund:

Synonyms: Otoferlin,Fer-1-like protein 2,OTOF,FER1L2,

Tissue Specificity: Isoform 1 and isoform 3 are found in adult brain. Isoform 2 is expressed in the fetus and in adult brain, heart, placenta, skeletal muscle and kidney.

Background: Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.

Sequence Similarities: Belongs to the ferlin family.

Molekulargewicht: 227 kDa

Gen-ID: 9381

Pathways: Sensory Perception of Sound, Synaptic Vesicle Exocytosis