KLF6 Antikörper (AA 38-205)

Produktnummer ABIN3042475

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLF6 in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für KLF6 Antikörper (AA 38-205) (ABIN3042475)

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KLF6 Antikörper

Bindungsspezifität: AA 38-205

Verwendungszweck: Anti-KLF6 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-KLF6 Antibody Picoband® (ABIN3042475). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human KLF6 recombinant protein (Position: E38-N205). Human KLF6 shares 92% and 90% amino acid (aa) sequences identity with mouse and rat KLF6, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Apr 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics 48 (1): 143-4. 2. Li D, Yea S, Dolios G et al. (October 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Res. 65 (20): 9216-25. 3. "Entrez Gene: KLF6 Kruppel-like factor 6"

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Andere Bezeichnung: KLF6

Hintergrund:

Synonyms: Krueppel-like factor 6,B-cell-derived protein 1,Core promoter element-binding protein,GC-rich sites-binding factor GBF,Proto-oncogene BCD1,Suppressor of tumorigenicity 12 protein,Transcription factor Zf9,KLF6,BCD1, COPEB, CPBP, ST12,

Tissue Specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Background: Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene which is located on 10p15.1. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.

Sequence Similarities: Belongs to the krueppel C2H2-type zinc-finger protein family.

Molekulargewicht: 37 kDa

Gen-ID: 1316

UniProt: Q99612