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KLF6 Antikörper (AA 38-205)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLF6 in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.
Produktnummer ABIN3042475

Kurzübersicht für KLF6 Antikörper (AA 38-205) (ABIN3042475)

Target

Alle KLF6 Antikörper anzeigen
KLF6 (Kruppel-Like Factor 6 (KLF6))

Reaktivität

  • 41
  • 28
  • 24
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte

Wirt

  • 37
  • 5
Kaninchen

Klonalität

  • 38
  • 4
Polyklonal

Konjugat

  • 23
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser KLF6 Antikörper ist unkonjugiert

Applikation

  • 32
  • 9
  • 6
  • 5
  • 4
  • 4
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 38-205

    Verwendungszweck

    Anti-KLF6 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-KLF6 Antibody Picoband® (ABIN3042475). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human KLF6 recombinant protein (Position: E38-N205). Human KLF6 shares 92% and 90% amino acid (aa) sequences identity with mouse and rat KLF6, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Rat
    1. Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Apr 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics 48 (1): 143-4. 2. Li D, Yea S, Dolios G et al. (October 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Res. 65 (20): 9216-25. 3. "Entrez Gene: KLF6 Kruppel-like factor 6"

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    KLF6 (Kruppel-Like Factor 6 (KLF6))

    Andere Bezeichnung

    KLF6

    Hintergrund

    Synonyms: Krueppel-like factor 6,B-cell-derived protein 1,Core promoter element-binding protein,GC-rich sites-binding factor GBF,Proto-oncogene BCD1,Suppressor of tumorigenicity 12 protein,Transcription factor Zf9,KLF6,BCD1, COPEB, CPBP, ST12,

    Tissue Specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

    Background: Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene which is located on 10p15.1. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.

    Sequence Similarities: Belongs to the krueppel C2H2-type zinc-finger protein family.

    Molekulargewicht

    37 kDa

    Gen-ID

    1316

    UniProt

    Q99612
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