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HRG Antikörper (AA 19-200)

Dieses Anti-HRG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HRG in WB und IHC. Geeignet für Human.
Produktnummer ABIN3042459

Kurzübersicht für HRG Antikörper (AA 19-200) (ABIN3042459)

Target

Alle HRG Antikörper anzeigen
HRG (Histidine-Rich Glycoprotein (HRG))

Reaktivität

  • 44
  • 22
  • 13
  • 2
Human

Wirt

  • 45
  • 31
  • 1
Kaninchen

Klonalität

  • 45
  • 32
Polyklonal

Konjugat

  • 57
  • 9
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HRG Antikörper ist unkonjugiert

Applikation

  • 65
  • 50
  • 37
  • 34
  • 9
  • 4
  • 4
  • 2
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 19-200

    Verwendungszweck

    Anti-HRG Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-HRG Antibody Picoband® (ABIN3042459). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human HRG recombinant protein (Position: V19-V200). Human HRG shares 71% and 69% amino acid (aa) sequences identity with mouse and rat HRG, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Hennis BC, Kluft C (Sep 1991). "KpnI RFLP in the human histidine-rich glycoprotein gene". Nucleic Acids Res 19 (15): 4311-4311. 2. "Entrez Gene: HRG histidine-rich glycoprotein" 3. Poon IK, Patel KK, Davis DS, Parish CR, Hulett MD (2011). "Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma". Blood 117 (7): 2093-101.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    HRG (Histidine-Rich Glycoprotein (HRG))

    Andere Bezeichnung

    HRG

    Hintergrund

    Synonyms: Histidine-rich glycoprotein,Histidine-proline-rich glycoprotein,HPRG,HRG,

    Tissue Specificity: Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). .

    Background: Histidine-rich glycoprotein (HRG) is a protein that in humans is encoded by the HRG gene. It is mapped to 3q27.3. HRG contains two cystatin-like domains and is located in plasma and platelets. The protein can bind heme, dyes and divalent metal ions. It also can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. HRG is thought to have multiple roles as a protein in the human blood, including roles in immunity, angiogenesis and coagulation.

    Molekulargewicht

    60 kDa

    Gen-ID

    3273

    UniProt

    P04196
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