FOXM1 Antikörper (AA 411-763)

Produktnummer ABIN3042402

Dieser Anti-FOXM1-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von FOXM1 in WB. Geeignet für Human.

Kurzübersicht für FOXM1 Antikörper (AA 411-763) (ABIN3042402)

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FOXM1 Antikörper

Bindungsspezifität: AA 411-763

Verwendungszweck: Anti-FOXM1 Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-FOXM1 Antibody (ABIN3042402). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu FOXM1

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Andere Bezeichnung: FOXM1

Hintergrund:

Synonyms: Forkhead box protein M1,Forkhead-related protein FKHL16,Hepatocyte nuclear factor 3 forkhead homolog 11,HFH-11,HNF-3/fork-head homolog 11,M-phase phosphoprotein 2,MPM-2 reactive phosphoprotein 2,Transcription factor Trident,Winged-helix factor from INS-1 cells,FOXM1,FKHL16, HFH11, MPP2, WIN,

Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

Sequence Similarities: Contains 1 fork-head DNA-binding domain.

Molekulargewicht: 36 kDa

Gen-ID: 2305

UniProt: Q08050

Pathways: Positive Regulation of Response to DNA Damage Stimulus