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FOXM1 Antikörper (AA 411-763)

Dieses Anti-FOXM1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FOXM1 in WB. Geeignet für Human.
Produktnummer ABIN3042402

Kurzübersicht für FOXM1 Antikörper (AA 411-763) (ABIN3042402)

Target

Alle FOXM1 Antikörper anzeigen
FOXM1 (Forkhead Box M1 (FOXM1))

Reaktivität

  • 50
  • 25
  • 22
  • 4
  • 3
  • 2
  • 2
  • 2
Human

Wirt

  • 40
  • 13
Kaninchen

Klonalität

  • 38
  • 15
Polyklonal

Konjugat

  • 33
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser FOXM1 Antikörper ist unkonjugiert

Applikation

  • 26
  • 20
  • 10
  • 8
  • 5
  • 4
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 411-763

    Verwendungszweck

    Anti-FOXM1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-FOXM1 Antibody Picoband® (ABIN3042402). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    1. Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA, Costa RH (March 1997). "Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues". Mol Cell Biol 17 (3): 1626-41. 2. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H (March 1998). "The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization". Genomics 46 (3): 435-42. 3. Wierstra I, Alves J (December 2007). "FOXM1, a typical proliferation-associated transcription factor". Biol. Chem. 388 (12): 1257-74.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    FOXM1 (Forkhead Box M1 (FOXM1))

    Andere Bezeichnung

    FOXM1

    Hintergrund

    Synonyms: Forkhead box protein M1,Forkhead-related protein FKHL16,Hepatocyte nuclear factor 3 forkhead homolog 11,HFH-11,HNF-3/fork-head homolog 11,M-phase phosphoprotein 2,MPM-2 reactive phosphoprotein 2,Transcription factor Trident,Winged-helix factor from INS-1 cells,FOXM1,FKHL16, HFH11, MPP2, WIN,

    Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

    Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

    Sequence Similarities: Contains 1 fork-head DNA-binding domain.

    Molekulargewicht

    36 kDa

    Gen-ID

    2305

    UniProt

    Q08050

    Pathways

    Positive Regulation of Response to DNA Damage Stimulus
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