FMO1 Antikörper (C-Term)

Produktnummer ABIN3042396

Dieses Anti-FMO1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FMO1 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FMO1 Antikörper (C-Term) (ABIN3042396)

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FMO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FMO1 Antikörper

Bindungsspezifität: AA 334-363, C-Term

Verwendungszweck: Anti-FMO1 Antibody Picoband®

Sequenz: AFPFLDESVV KVEDGQASLY KYIFPAHLQK

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-FMO1 Antibody Picoband® (ABIN3042396). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human FMO1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: FMO1 flavin containing monooxygenase 1". 2. Cashman JR (2004). "The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development".Drug Discov. Today 9 (13): 574-581. 3. Dolphin C, Shephard EA, Povey S et al. (1991). "Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)".J. Biol. Chem. 266 (19): 12379-85.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu FMO1

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Andere Bezeichnung: FMO1

Hintergrund:

Synonyms: Dimethylaniline monooxygenase [N-oxide-forming] 1,1.14.13.8,Dimethylaniline oxidase 1,Fetal hepatic flavin-containing monooxygenase 1,FMO 1,FMO1,

Tissue Specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Background: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene.

Sequence Similarities: Belongs to the FMO family.

Molekulargewicht: 60 kDa

Gen-ID: 2326

UniProt: Q01740