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MICB Antikörper (N-Term)

Dieses Anti-MICB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MICB in WB und FACS. Geeignet für Human und Maus.
Produktnummer ABIN3042366

Kurzübersicht für MICB Antikörper (N-Term) (ABIN3042366)

Target

Alle MICB Antikörper anzeigen
MICB (MHC Class I Polypeptide-Related Sequence B (MICB))

Reaktivität

  • 16
  • 1
  • 1
Human, Maus

Wirt

  • 8
  • 8
Kaninchen

Klonalität

  • 8
  • 8
Polyklonal

Konjugat

  • 12
  • 2
  • 1
  • 1
Dieser MICB Antikörper ist unkonjugiert

Applikation

  • 7
  • 6
  • 6
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 3
    • 2
    • 1
    • 1
    • 1
    AA 23-48, N-Term

    Verwendungszweck

    Anti-MICB Antibody Picoband®

    Sequenz

    AEPHSLRYNL MVLSQDESVQ SGFLAE

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-MICB Antibody Picoband® (ABIN3042366). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human MICB.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    1. Bahram S, Bresnahan M, Geraghty DE, Spies T (Aug 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proc Natl Acad Sci U S A 91 (14): 6259-63. 2. "Entrez Gene: MICB MHC class I polypeptide-related sequence B". 3. Leelayuwat C, Townend DC, Degli-Esposti MA et al. (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I.".Immunogenetics 40 (5): 339-51.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    MICB (MHC Class I Polypeptide-Related Sequence B (MICB))

    Andere Bezeichnung

    MICB

    Hintergrund

    Synonyms: MHC class I polypeptide-related sequence B,MIC-B,MICB ,PERB11.2 ,

    Tissue Specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. .

    Background: MHC class I polypeptide-related sequence B is a protein that in humans is encoded by the MICB gene. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules, however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.

    Sequence Similarities: Belongs to the MHC class I family. MIC subfamily.

    Molekulargewicht

    60-65 kDa

    Gen-ID

    4277

    UniProt

    Q29980

    Pathways

    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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