Menin Antikörper (AA 301-615)

Produktnummer ABIN3042359

Produktdetails anti-Menin Antikörper

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Bindungsspezifität: AA 301-615

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Menin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Menin(MEN1) detection. Tested with WB in Human,Mouse.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Menin(MEN1) detection. Tested with WB in Human,Mouse.
Gene Name: multiple endocrine neoplasia I
Protein Name: Menin

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Menin recombinant protein (Position: P301-L615). Human Menin shares 93% and 94% amino acid (aa) sequence identity with mouse and rat Menin, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for Menin is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Andere Bezeichnung: MEN1 (MEN1 Produkte)

Synonyme: MEAI antikoerper, SCG2 antikoerper, menin antikoerper, meai antikoerper, scg2 antikoerper, AW045611 antikoerper, menin 1 antikoerper, menin 1 L homeolog antikoerper, multiple endocrine neoplasia I antikoerper, multiple endocrine neoplasia 1 antikoerper, MEN1 antikoerper, men1 antikoerper, men1.L antikoerper, Men1 antikoerper

Hintergrund: The MEN1 gene encodes menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that MEN1 is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. What's more, MEN1 was essential to maintain MLL-associated myeloid transformation.

Synonyms: MEA 1 antibody|MEA1 antibody|MEN 1 antibody|MEN1 antibody|MEN1_HUMAN antibody|Menin antibody|Multiple Endocrine Adenomatosis 1 antibody|Multiple Endocrine Neoplasia 1 antibody|SCG 2 antibody|SCG2 antibody|Suppressor Candidate Gene 2 antibody|Wermer syndrome antibody|ZES antibody|Zollinger Ellison Syndrome antibody

Gen-ID: 4221

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity