PROC Antikörper (AA 446-461)

Produktnummer ABIN3032367

Produktdetails anti-PROC Antikörper

Target: PROC (Vitamin K-dependent protein C (PROC))

Bindungsspezifität: AA 446-461

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PROC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids 446-461 (HGHIRDKEAPQKSWAP) were used as the immunogen for this Protein C antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Protein C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Protein C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Andere Bezeichnung: Protein C (PROC Produkte)

Synonyme: proc antikoerper, si:ch1073-188c16.3 antikoerper, zgc:63987 antikoerper, PROC antikoerper, APC antikoerper, PC antikoerper, PROC1 antikoerper, THPH3 antikoerper, THPH4 antikoerper, proc1 antikoerper, MGC64425 antikoerper, PA antikoerper, protein C, inactivator of coagulation factors Va and VIIIa antikoerper, protein C (inactivator of coagulation factors Va and VIIIa), a antikoerper, protein C (inactivator of coagulation factors Va and VIIIa) antikoerper, protein C, inactivator of coagulation factors Va and VIIIa S homeolog antikoerper, vitamin K-dependent protein C antikoerper, prosaposin antikoerper, protein C antikoerper, proline rich protein HaeIII subfamily 1 antikoerper, PROC antikoerper, proca antikoerper, proc.S antikoerper, proc antikoerper, CpipJ_CPIJ000393 antikoerper, CpipJ_CPIJ002754 antikoerper, CpipJ_CPIJ003717 antikoerper, CpipJ_CPIJ003718 antikoerper, CpipJ_CPIJ014440 antikoerper, CpipJ_CPIJ018032 antikoerper, CpipJ_CPIJ018737 antikoerper, PSAP antikoerper, Proc antikoerper, PRH1 antikoerper

Substanzklasse: Viral Protein

Hintergrund: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of Protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated Protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for Protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated Protein C concentrates had been described in case reports and in one uncontrolled series.

UniProt: P04070