PMVK Antikörper (Middle Region)

Produktnummer ABIN3032231

Produktdetails anti-PMVK Antikörper

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMVK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human PMVK (EQSRQQRGWVFTPGVDD) was used as the immunogen for this PMVK antibody (100% homologous in human and mouse).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the PMVK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the PMVK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu PMVK

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Andere Bezeichnung: PMVK (PMVK Produkte)

Synonyme: MPK_Bm antikoerper, F5M6.9 antikoerper, F5M6_9 antikoerper, zgc:162701 antikoerper, HUMPMKI antikoerper, PMK antikoerper, PMKA antikoerper, PMKASE antikoerper, 1110011E12Rik antikoerper, 2900002L22Rik antikoerper, AV001327 antikoerper, phosphomevalonate kinase antikoerper, GHMP kinase family protein antikoerper, PMVK antikoerper, Mpk antikoerper, AT1G31910 antikoerper, CpipJ_CPIJ015413 antikoerper, Bm1_05275 antikoerper, pmvk antikoerper, LOAG_11811 antikoerper, Tsp_06629 antikoerper, LOC100282968 antikoerper, Pmvk antikoerper

Hintergrund: Phosphomevalonate kinase is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence(PTS-1), Ser-Arg-Leu, at the C terminus of the protein.

UniProt: Q15126