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Peroxiredoxin 3 Antikörper (AA 110-256)

Der Kaninchen Polyklonal Anti-Peroxiredoxin 3-Antikörper wurde für WB, ICC und IHC (p) validiert. Er ist geeignet, Peroxiredoxin 3 in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN3032189

Kurzübersicht für Peroxiredoxin 3 Antikörper (AA 110-256) (ABIN3032189)

Target

Alle Peroxiredoxin 3 (PRDX3) Antikörper anzeigen
Peroxiredoxin 3 (PRDX3)

Reaktivität

  • 93
  • 44
  • 27
  • 2
Human, Ratte, Maus

Wirt

  • 97
  • 8
  • 1
  • 1
Kaninchen

Klonalität

  • 91
  • 15
Polyklonal

Konjugat

  • 55
  • 11
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Peroxiredoxin 3 Antikörper ist unkonjugiert

Applikation

  • 77
  • 39
  • 25
  • 22
  • 22
  • 19
  • 13
  • 13
  • 12
  • 12
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 15
    • 13
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-256

    Aufreinigung

    Antigen affinity

    Immunogen

    Human partial recombinant protein (AA 110-256) was used as the immunogen for this PRDX3 antibody.

    Isotyp

    IgG
  • Applikationshinweise

    The stated application concentrations are suggested starting amounts. Titration of the PRDX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC: 0.5-1 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the PRDX3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    Peroxiredoxin 3 (PRDX3)

    Andere Bezeichnung

    PRDX3 (Peroxiredoxin 3)

    Hintergrund

    Peroxiredoxin 3, also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human protein shares 86 % amino acid sequence similarity with mouse, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of Peroxiredoxin 3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.

    Gen-ID

    10935

    Pathways

    Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
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