MUC1 Antikörper (AA 1067-1083)

Produktnummer ABIN3031861

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MUC1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MUC1 Antikörper (AA 1067-1083) (ABIN3031861)

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MUC1 Antikörper

Bindungsspezifität: AA 1067-1083

Aufreinigung: Antigen affinity

Immunogen: Amino acids 1067-1083 (QELQRDISEMFLQIYKQ-human) were used as the immunogen for this MUC1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the MUC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MUC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC1

Hintergrund: Mucin 1 protein is encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Family members are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. MUC1 is a transmembrane protein normally expressed on the apical borders of secretory epithelial cells. Overexpression is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. It stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This protein also can suppress pulmonary innate immunity, and its anti-inflammatory activity may play an important modulatory role during microbial infection.

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling