MFN2 Antikörper (AA 601-757)

Produktnummer ABIN3031819

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MFN2 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für MFN2 Antikörper (AA 601-757) (ABIN3031819)

Target: MFN2 (Mitofusin 2 (MFN2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MFN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MFN2 Antikörper

Bindungsspezifität: AA 601-757

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 601-757) was used as the immunogen for this MFN2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the MFN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MFN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Andere Bezeichnung: MFN2

Hintergrund: Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. This gene is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. It has been found that MFN2 triggers mitochondrial energization, at least in part, by regulating OXPHOS expression through signals that are independent of its role as a mitochondrial fusion protein. And it contributes to the maintenance and operation of the mitochondrial network. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations of, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.

Gen-ID: 9927

Pathways: Skeletal Muscle Fiber Development