ANP32E
Reaktivität: Human
IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
Alexa Fluor 680
Applikationshinweise
Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Western Blot (0.5-2 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
LANP-L antikoerper, LANPL antikoerper, ANP32E antikoerper, wu:fb22e03 antikoerper, wu:fc04c12 antikoerper, wu:fc19a08 antikoerper, wu:fc79f04 antikoerper, wu:fi39c10 antikoerper, zgc:65995 antikoerper, zgc:85827 antikoerper, DKFZp459A0729 antikoerper, 2810018A15Rik antikoerper, AI047746 antikoerper, AI326868 antikoerper, CPD1 antikoerper, mLANP-L antikoerper, MGC180507 antikoerper, acidic nuclear phosphoprotein 32 family member E antikoerper, acidic (leucine-rich) nuclear phosphoprotein 32 family, member E antikoerper, acidic nuclear phosphoprotein 32 family member E L homeolog antikoerper, acidic leucine-rich nuclear phosphoprotein 32 family member E-like antikoerper, ANP32E antikoerper, anp32e antikoerper, Anp32e antikoerper, anp32e.L antikoerper, LOC100349957 antikoerper, LOC100355663 antikoerper
Hintergrund
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-L, LANP-like protein, LANPL, PHAP III