HSD17B2 Antikörper (AA 373-387)

Produktnummer ABIN3031272

Der Kaninchen Polyklonal anti-HSD17B2 Antikörper (ABIN3031272) detektiert spezifisch HSD17B2 in WB, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für HSD17B2 Antikörper (AA 373-387) (ABIN3031272)

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD17B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-HSD17B2 Antikörper

Bindungsspezifität: AA 373-387

Aufreinigung: Antigen affinity

Immunogen: Amino acids 373-387 (MPRALRMPNYKKKAT-human) were used as the immunogen for this HSD17B2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the HSD17B2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu HSD17B2

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Andere Bezeichnung: HSD17B2

Hintergrund: HSD17B2(17-beta-hydroxysteroid dehydrogenase II), also called 17-beta-HSD II, is an enzyme with 387 amino acids, a predicted molecular weight of 42,782D, and associate with the membranes of the endoplasmic reticulum. The type 2 enzyme is capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And it activity distinguishing between disease-free and diseased endometria. It efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis